Glipizide pharmacokinetics

Chung M, Kourides I, Canovatchel W, Sutfin T, Messig M, Chaiken RL. Pharmacokinetics and pharmacodynamics of extended-release glipizide GITS compared with immediate-release glipizide in patients with type II diabetes mellitus. J Clin Pharmacol 2002 42(6) 651-7. 

Kidd RS, Straughn AB, Meyer MC, et al Pharmacokinetics of chlorpheniramine, phenytoin, glipizide and nifedipine in an individual homozygous for the CYP2C9 3 allele. Pharmacogenetics 9 71-80,1999 Kinirons MT, Crome P Clinical pharmacokinetic considerations in the elderly an update. Clin Pharmacokinet 33 302-312,1997... 

Groop L, Groop PH, Stemnan S, Saloranta C, Totterman KJ, Fyhrquist F, Melander A. Comparison of pharmacokinetics, metabolic effects and mechanisms of action of glybnride and glipizide during longterm treatment. Diabetes Care 1987 10(6) 71-78. 

Niemi M, Backman JT, Neuvonen M, Neuvonen PJ, Kivisto KT. Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide. Clin Pharmacol Ther (St. Louis, MO, United States) 2001 69 400-406. 

A study in 12 healthy subjects found that posaconazole 400 mg twice daily for 10 days had no significant effects on the steady-state pharmacokinetics of glipizide 10 mg daily, but there was a small significant decrease in blood glucose levels following concurrent use. Glipizide did not affect the pharmacokinetics of posaconazole. ... 

Courtney R, Sansone A, Statkevich P, Martinho M, Laughlin M. Assessment of the pharmacokinetic (PK), pharmacodynamic (PD) interaction potential between posaconazole and glipizide in healthy volunteers. Clin Pharmacol Ther (2003) 73, P45. 

Sulphonylureas A study in six type 2 diabetics found that a single 20-mg dose of nifedipine had no effect on the pharmacokinetics of glipizide 5 to 30 mg daily. Similarly, nimodipine caused no change in the pharmacokinetics of ibenciamide in 11 patients. ... 

Two studies in type 2 diabetics found that ranitidine 150 mg increased the AUC of glipizide by 29% and 34%, and reduced the expected rise in blood sugar levels after a meal by 22%. However, another study by the same research group reported that ranitidine 300 mg had no significant effects on either the pharmacokinetics or the effects of glipizide, except that the absorption was delayed. ... 

Orlistat improved glycaemic control, which resulted in the need to reduce the dose of glibenclamide (glyburide) or glipizide in almost half the patients in one study. In other studies, orlistat also reduced the dose requirement for metformin and for insulin. Orlistat did not alter the pharmacokinetics of glibenclamide or metformin. Orlistat and cimetidine may have contributed to a case of metformin-associated lactic acidosis. The manufacturers recom-... 

In healthy subjects, pioglitazone 45 mg daily for 7 days did not alter the steady-state pharmacokinetics of glipizide 5 mg daily. - ... 

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