Glipizide drug interactions

Drug Interactions Increased prothrombin time after warfarin administration Phenytoin Cyclosporine Tolbutamide Tacrolimus Glyburide Glipizide Rifampin Cisapride Terfenadine Astemizole Theophylline ... 

Johnson JF, Dobmeier ME. Symptomatic hypoglycemia secondary to a glipizide-trimethoprim/sulfamethoxazole drug interaction. DICP Ann Pharmacother (1990) 24, 250-1. 

Drug/Food interactions Absorption of glipizide is delayed by approximately 40 minutes when taken with food the drug is more effective when given approximately 30 minutes before a meal. The other sulfonylureas may be taken with food. 

Ann Sulin is taking a sulfonylurea compound known as glipizide to treat her diabetes. The sulfony-lureas act on the K atp channels on the surface of the pancreatic (5 cells. The binding of the drug to these channels closes K+ channels (as do elevated ATP levels), which, in turn, increases Ca + movement into the interior of the p cell. This influx of calcium modulates the interaction of the insulin storage vesicles with the plasma membrane of the p cell, resulting in the release of insulin into the circulation. 

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