Isocyanates cyclohexyl

Polyurethane dispersions (PUD s) are usually high-performance adhesives based on crystalline, hydrophobic polyester polyols, such as hexamethylene adipate, and aliphatic diisocyanates, such as methylene bis(cyclohexyl isocyanate) (H12MDI) or isophorone diisocyanate (IPDI). These PUD s are at the more expensive end of the waterborne adhesive market but provide excellent performance. 

It is of note that hypoglycemic activity is maintained even when the aromatic ring is fused onto a carbocyclic ring. Chlor-sulfonation of hydrindan gives chloride, 206. Reaction of the sulfonamide (207) obtained from that intermediate with cyclohexyl isocyanate leads to glyhexamide (208). ... 

This product is then reacted with cyclohexyl isocyanate to give glipizide. 

Cyclohexyl isocyanate A cetoh examide Glipizide Gliquidone... 

A prepolymer is made first by charging Pluracol E2000 [1000.0 g, 1.0 eq., poly(ethylene oxide), 56 OH, BASF] to a suitable container equipped with a mechanical stirrer and a nitrogen gas inlet. Flush the container with dry nitrogen and add Desmodur W (264.0 g, 2.0 eq., 4,4 -methylene-bis(cyclohexyl isocyanate), 31.8% NCO, Bayer). While maintaining a positive N2 pressure on the reaction mixture, stir and heat at 80°C for 2 h. Cool the product to room temperature and check the NCO content (theory = 3.32 %). It might be necessary to warm the highly viscous prepolymer to take samples for titration. To a portion of this prepolymer (250.0 g, 0.2 eq.), add Dabco T-12 (0.25 g, dibutyltin dilaurate,... 

Hydroxy-4-methylthiazole-2(3//)thione carbamates, e.g. the cyclohexyl derivative 336, are precursors for monoalkylaminium cation radicals, which cannot be prepared from 2-thioxopyridinyloxycarbamates. The carbamate is obtained from 3-hydroxy-4-methylthiazole-2(3//)-thione and cyclohexyl isocyanate. When irradiated in the presence of malonic acid and /-butyl hydrogen sulphide it yields the cyclohexylaminium cation... 

CYCLOHEXYL ISOCYANATE 12.0255 -3.4717E+03 1.2043E+00 -1.3523E-02 7.6331E... 

Optical lenses were prepared by Bojkova et al. (3) by reacting 1,1,1 -tris(hydroxy-methyl)propane with 4,4 -methylenebis(cyclohexyl isocyanate) and then postreacting with 2-mercaptoethyl sulfide. 

Changing the nature of the triazine substitution pattern to the l,3,5-triazine-2,4-dione system leads to another series of herbicides, of which the best example is hexazinone (1) (75USP3902887). It is built up from cyanamide which is converted in several steps to the guanidine (2). Reaction with cyclohexyl isocyanate then gives an intermediate which can be cyclized to hexazinone (Scheme 2). 

When a toluene solution of a mixture of cyclotrisilane 34 and cyclohexyl isocyanate (or f-butyl isocyante) was heated at 70 °C, cyclic di- and trisiloxanes 37 and 38, i.e. the cyclic dimer and trimer of the silanone 36, were obtained together with the corresponding isonitrile RN=C. The formation of 37 as well as 38 was completely suppressed in the presence of hexamethylcyclotrisiloxane (19 D3) instead, quantitative conversion of 35 into 39, the formal insertion product of the silanone 36 into the Si—O bond of D3, occurred (Scheme 14). Since neither cyclodisiloxane 37 nor cyclotrisiloxane 38 reacted with D3 under the reaction conditions, the possibility that 37 or 38 is the precursor of 39 was ruled out. Whereas the oxidation of 35 with cyclohexyl and t-butyl isocyanates proceeded with exclusive formation of 37 and 38 (as the silicon-containing compounds) the reaction of 35 with phenyl isocyanate resulted in the formation of 37 in low yield. Furthermore, in this case the presence of D3 did not totally suppress the formation of 37. According to the authors, these results indicate that the oxidation of 35 with cyclohexyl and f-butyl isocyanates appears to use other reaction channels than that with phenyl isocyanate. 

Umezawa and co-workers9 have reported a new synthesis of the tetracyclic lactam (19), which is a key intermediate in Torssell s synthesis of lycorine (cf. Vol. 9, p. 139) the Japanese work (Scheme 2), therefore, represents a formal synthesis of the alkaloid. The cyclohexyl isocyanate (15) (trans-diequatorial aryl and isocyanate groups) cyclized to a tricyclic lactam, which by reduction with a hydride and hydrolysis gave the ketone (18). The tetracyclic ketone (16) was converted into the 2,3-ene (17) by a Cope elimination reaction, and the synthesis of compound (19) was completed by transposition of the lactam carbonyl group from C-5 to C-7. 

Sodium nitrite Hydrogen chloride Ammonia p-Aminoacetophenone Sulfur dioxide Cyclohexyl isocyanate ... 

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