Glipizide toxicity

Glipizidinduceret toksisk hepatitis. [Glipizide induced toxic hepatitis.] Ugeskr Laeger 1986 148(13) 771-2. 

A 39-year-old man with schizophrenia and diabetes, who had taken clozapine 300 mg/day and glipizide 10 mg/day for a year, took lisinopril 5 mg/day for newly diagnosed hypertension. On several occasions afterwards he had roughly a doubling of his blood concentrations of clozapine and norclozapine. He had typical effects of clozapine toxicity. After replacement of lisinopril by diltiazem, the blood concentrations of clozapine and norclozapine returned to the values that were present before lisinopril was introduced. 

CICLOSPORIN SULPHONYLUREAS- GUPIZIDE May T plasma concentrations of ciclosporin Glipizide inhibits CYP3A4-mediated metabolism of ciclosporin Monitor plasma ciclosporin levels to prevent toxicity... 

Note Glipizide is a sulfonamide and can be absorbed systemically. Sulfonamides can produce severe, possibly fatal, reactions such as toxic epidermal necrolysis and Stevens-Johnson syndrome... 

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