Ranitidine Glipizide

Cronqvist, J. Nilsson-Ehle, I. Determination of acyclovir in human serum hy hi -performance liquid chromatography. J.Liq.Chromatogr., 1988, 11, 2593-2601 [serum non-interfering acetaminophen, allopurinol, baclofen, carbacholine, cefuroxime, chlorpropamide, cilastatin, cloxacillin, diazepam, di-cumarol, digoxin, flucloxacillm, furosemide, fusidic acid, fusidic, glipizide, heparin, hydrochlorothiazide, imipenem, insulin, isoniazid, ketoprofen, metronidazole, naproxen, perphenazine, phenytoin, prednisolone, propranolol, p3razinamide, p3ridoxine, ranitidine, rifampicin, rifampin, spironolactone, streptomycin, sulfamethoxazole, trimethoprim, warfarin]... 

On the whole cimetidine and ranitidine do not appear to significantly alter diabetic control with sulphonylureas, although cases of adverse effects have been seen when glibenclamide was given with ranitidine, and when gliclazide or glipizide were given with cimetidine. 

Two studies in type 2 diabetics found that ranitidine 150 mg increased the AUC of glipizide by 29% and 34%, and reduced the expected rise in blood sugar levels after a meal by 22%. However, another study by the same research group reported that ranitidine 300 mg had no significant effects on either the pharmacokinetics or the effects of glipizide, except that the absorption was delayed. ... 

MacWalterRS, El Debani AH, Feeley J, Stevenson IH. Potentiation l ranitidine of thehy-pc lycaemic re nse to glipizide in < abetic patients. BrJClinPharmacol( 9Z5) 19,121P-122P. 

Stevenson IH, El Debani AH, MicWalter RS. Glipizide phannacokinetics and effect in diabetic patients given ranitidine. Acta Pharmacol Toxicol (Coperh) (1986) 59 (Siq>pl 4), 97. 

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