Genome activity regulation

The molecular lever mechanisms that permit muscle function to directly regulate the genomic activity of strained bone cells, including their phenotypic expression, when combined together with electric field effects and contraction frequency energetics, provides a biophysical basis for an earlier hypothesis of epigenetic regulation of skeletal tissue adaptation [135, 136, 146, 147]. 

Hormonal Regulation of Genome Activity in Higher Plants... 

Although we have no prior reason to expect that the modes of action of plant hormones and steroid hormones are similar, we can expect that the regulation of genome activity is similar in all eucaryotic cells. Evidence for the presence of adenyl cyclase specific for 3, 5 -cyclic AMP in plants is controversial (82). 

The question whether hormones regulate genome activity can only be answered by speculations for evidence is limited. We know of only two instances of hormonal induction of synthesis of specific mRNA s. The cellular mechanisms that allow an increase in the amount of translatable mRNA s at any given time of hormone... 

Dihydroxyvitamin (283) is the endogenous ligand for the vitamin receptor (VDR). It modulates genomic function in a tissue and developmentaHy specific manner and affects ceU proliferation, differentiation, and mineral homeostasis (74). Vitamin mobilizes calcium from the bone to maintain plasma Ca " levels. Vitamin and VDR are present in the CNS where they may play a role in regulating Ca " homeostasis. Vitamin D has potent immunomodulatory activity in vivo. 

Wetzel MA, Steele AD, Eisenstein TK, Adler MW, Henderson EE, Rogers TJ (2000) Mu-opioid induction of monocyte chemoattractant protein-1, RANTES, and IFN-gamma-inducible protein-10 expression in human peripheral blood mononuclear cells. J Immunol 165 6519-6524 Widmer U, Manogue KR, Cerami A, Sherry B (1993) Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines. J Immunol 150 4996-5012 Ye RD (2001) Regulation of nuclear factor kappaB activation by G-protein-coupled receptors. [Review] [136 refs]. J Leukoc Biol 70 839-848... 

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