Genomic regulation

Khorasanizadeh S (2004) The nucleosome from genomic organization to genomic regulation. Cell 116 259-272... 

Dellaert proposed two models of development, a complex model and a simplified model. Both models assume that agents are made of cells controlled by genomes. As such, this section presents the model of genomic regulation in both models. This is followed in the next section by an explanation of how the simple model can guide a process of development, which starts with a single cell and concludes with a complete organism. 

A graphical representation of genomic regulation in the complex model of development. 

At the genomic level, an RBN models genomic regulation. The state of a cell is described via its state vector. A state vector may be viewed as a set of the proteins that exist in a cell at some moment in time. However, even in this minimal model, two other properties of real cells must be included cell division and spatial patterning. 

So far, the best understood examples of genomic regulation of neuronal function stem from the actions of gonadal and adrenal steroids and thyroid hormone, and many of these actions are involved in the plasticity of behavior that results from hormonal secretion, such as changes in aggressive and reproductive behavior and... 

Program of Genes and Diseases, Center for Genomic Regulation, Barcelona, Spain... 

Li H, Minarovits J. Host-cell dependent expression of latent Epstein-Barr virus genomes regulation by DNA methylation. Adv Cancer Res 2003 89 133-56. 

N. Alexandrov, N. Go, Abstract presented at the Bioinformatics Genome Regulation Structure Conference (Novosibirsk) 1998. 

Hippel, P. H. von, Revzin, A., Gross, C. A., Wang, A. C. (1974). Non-specific DNA binding of genome regulating proteins as a biological control mechanism I. The lac operon Equilibrium aspects. Proc. Natl. Acad. Sci. USA 71,4808-4812. 

Ohtake F, Kato S (2012) The E3 ubiquitin ligase activity of transcription factor AhR permits non-genomic regulation of biological pathways. In Pohjanvirta R (ed) The AH receptor in biology and toxicology. Willey, New York, pp 143-156... 

O Kane C.J. and Gehring W.J. 1987. Detection in situ of genomic regulator elements in Drosophila. Proc. Natl. Acad. Sci 84 9123-9127. 

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