Genetic control of the immune response

Nussbaum SR, Lin CS, Potts JT, Rosenthal AS, Rosenblatt M. Development of monoclonal antibodies against parathyroid hormone genetic control of the immune response to human PTH. Methods Enzymoi 1985 109 625-38. 

BERZOFSKY, J.A., SCHECHTER, A.N., SHEARER, G.M. SACHS, D.H. (1977) Genetic control of the immune response to staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments. Journal of Experimental Medicine, 145, 111-122. 

Levine BB, Ojeda A, Benacerraf B (1963) Studies of artificial antigens. III. The genetic control of the immune response to hapten-poly-L-lysine conjugates in guinea pigs. J Exp Med 118 953-957... 

Solley O, Gleich J, Jordan RE, Schroeter AL (1976) The late phase of the immediate wheal-and-flare skin reaction. Its dependence upon IgE antibodies. J Clin Invest 58 408 Spark RP (1971) Fatal anaphylaxis due to oral penicillin. Clin Pathol 56 407 Spengler H, de Week AL (1977) Evaluation of genetic control of the immune response to penicillin in man. Monogr Allergy 11 116... 

The presentation of amino acid sequences in Chapter 4 is again selective, including mainly those of human, mouse, and rabbit immunoglobulins. Selected sequences are presented in other sections where relevant, in particular where they serve to define principles underlying the construction of the antibody molecule or to illuminate the genetic control of the immune response. The Atlas of Protein Structure, published periodically, is a comprehensive source of amino acid sequences (Margaret O. DayhofF, ed., The National Biomedical Research Foundation, Silver Spring, Maryland). 

We were unable to avoid some redundancy. For example, it seemed necessary to consider allotypy, idiotypy, and amino acid sequences in separate chapters. Yet each subject is intimately related to the genetic control of the immune response. Therefore, similar generalizations are sometimes drawn from the data presented in the three sections. Chapter 12 on theories of the genetic basis of structural variability attempts to draw these discussions together. 

Rude, E. and Gunther, E. (1975). Genetic control of the immune response to synthetic polypeptides in rats and mice. In Proc. of the 2nd Internat. Congr. Immunol. (In press)... 

Two inbred guinea pig strains, 2 and 13 (developed by Sewall Wright from a small closed colony), as well as random-bred lines, have been used to study the genetic control of specific immune responsiveness. The synthetic polypeptide antigens used in those studies are described in Table 4.1. 

Studies with a variety of genetically modified mice have shed new light on the complex relationship between the protective and pathological immune responses controlling parasite infections. TNF and NO are important components of the pathological response accompanying the expulsion of a gastrointestinal nematode parasite. In the absence of TNF-R1 or iNOS, mice do not develop the severe villus atrophy and mucosal mastocytosis that usually accompany infection with T. spiralis, but their ability to expel the... 

Mendlovic, F., Tarrab-Hazdai, R., Puri, J. and Arnon, R. (1 989) Genetic control of immune response to a purified Schistosoma mansoni antigen. I. Effect of MHC class II antigens on the cellular, humoral and protective responses. Parasite Immunology 11, 667-682. 

Animals to be used for immunological research show pronounced differences in their capacity to respond to specific antigens, including those containing carbohydrates. Such differences are genetically controlled and the selection of animals for immunization should be on the basis of a preliminary test. It is well to immunize a group of animals for short periods, and select those individuals which give the best response in preliminary trials for futher immunization and for production of antibodies. 

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