Control of the Immune Response

Baigent SM (2001) Peripheral cor ticotr opin-releasing hormone and ui ocortin in tire control of the immune response. Peptides 22 809-820. 

Nussbaum SR, Lin CS, Potts JT, Rosenthal AS, Rosenblatt M. Development of monoclonal antibodies against parathyroid hormone genetic control of the immune response to human PTH. Methods Enzymoi 1985 109 625-38. 

Inhibition of the normal immune response results from a gradual destruction of lymphoid tissue, followed by a decline in antibody production and a decrease in the numbers of eosinophils, basophils, and lymphocytes. The reduction in T-lymphocyte counts by glucocorticoids can occur acutely as a result of the redistribution of these cells from the intravascular space to the spleen, lymph nodes, and bone marrow. Thus an increase in the neutrophil count is commonly observed after glucocorticoid administration. The major suppressive effects of glucocorticoids on the inflamniatory response and the immune system appear to be through the modulation of cytokine production via an inhibition of nuclear factor kappa B (NF-kB) expression and nuclear translocation. Cytoldnes released from immunocompetent cells mediate both the acute and chronic phases of inflammation and participate in the control of the immune response (see Chapter 22). 

BERZOFSKY, J.A., SCHECHTER, A.N., SHEARER, G.M. SACHS, D.H. (1977) Genetic control of the immune response to staphylococcal nuclease. III. Time-course and correlation between the response to native nuclease and the response to its polypeptide fragments. Journal of Experimental Medicine, 145, 111-122. 

H. Wekerle, A. Fltigel and H. Neumann, TSTeuronal control of the immune response in the central nervous system from pathogenesis to therapy, in P. Patterson, C. Kordon and Y. Christen (eds), Neuro-Immune Interactions in Neurologic and Psychiatric Disorders (Berlin Springer, 2000), pp.111-23 M. Kubera, and M. Maes, Serotonin-immune interactions in major depression, in Patterson, Kordon and Christen (eds), Neuro-Immune Interactions, pp.79-87. 

Levine BB, Ojeda A, Benacerraf B (1963) Studies of artificial antigens. III. The genetic control of the immune response to hapten-poly-L-lysine conjugates in guinea pigs. J Exp Med 118 953-957... 

Solley O, Gleich J, Jordan RE, Schroeter AL (1976) The late phase of the immediate wheal-and-flare skin reaction. Its dependence upon IgE antibodies. J Clin Invest 58 408 Spark RP (1971) Fatal anaphylaxis due to oral penicillin. Clin Pathol 56 407 Spengler H, de Week AL (1977) Evaluation of genetic control of the immune response to penicillin in man. Monogr Allergy 11 116... 

The presentation of amino acid sequences in Chapter 4 is again selective, including mainly those of human, mouse, and rabbit immunoglobulins. Selected sequences are presented in other sections where relevant, in particular where they serve to define principles underlying the construction of the antibody molecule or to illuminate the genetic control of the immune response. The Atlas of Protein Structure, published periodically, is a comprehensive source of amino acid sequences (Margaret O. DayhofF, ed., The National Biomedical Research Foundation, Silver Spring, Maryland). 

We were unable to avoid some redundancy. For example, it seemed necessary to consider allotypy, idiotypy, and amino acid sequences in separate chapters. Yet each subject is intimately related to the genetic control of the immune response. Therefore, similar generalizations are sometimes drawn from the data presented in the three sections. Chapter 12 on theories of the genetic basis of structural variability attempts to draw these discussions together. 

Rude, E. and Gunther, E. (1975). Genetic control of the immune response to synthetic polypeptides in rats and mice. In Proc. of the 2nd Internat. Congr. Immunol. (In press)... 

Dead or live bacteria may be effective to stimulate inflammatory reactions of phagocytic cells against tumor cells. The best-characterized treatment is the use of Bacillus Calmette Guerin (BCG) in the case of bladder cancer where activation of the immune response is capable of controlling tumor growth. 

Fig. (2). Strategy for the identification of gel-separated (2D-SDS-PAGE) proteins that are part of the immune response of Drosophila. Blood from control and immune-challenged flies was collected and subjected to 2D-SDS-PAGE, immune-induced (-I-) or repressed (-) stained spots were excised, subjected to proteolysis e.g. trypsin), and the peptides fragments analyzed by MS and/or MS/MS.

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