Schistosoma mansoni egg antigens

Okano, M., Satoskar, A.R., Nishizaki, K. and Harn, D.A. Jr (2001) Lacto-N-fucopentaose III found on Schistosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. The Journal of Immunology 1 67, 442-450. 

Hamilton, J.V., Chiodini, P.L., Fallon, P.G. and Doenhoff, M.J. (1999) Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KFH) and serodiagnostic Schistosoma mansoni egg antigens. Parasitology 11 8, 83-90. 

Fig. 1. Changes in airway resistance (cm of H20/mm/s) in allergic mice following methacholine administration. CBA/J mice were sensitized with either Schistosoma mansoni egg antigen (SEA) or cockroach antigen (CRA) and lung function monitored at 24 h postchallenge with the respective antigen. Mice were compared to sensitized, vehicle-challenged controls. Data represents mean SE of changes in resistance from at least four mice per group.

MIP-la and CCR2 were deleted from mice using homologous recombination techniques. Mice were sensitized to PPD from Mycobacteria or Schistosoma mansoni egg antigen and were then injected intravenously with either Sephadex beads coated with PPD (Thl-type model) or SEA (Th2-type model). Cytokines and lesion morphology was performed on lungs removed from MIP-la knock-out and CCR2 knock-out mice 4 d after PPD or SEA beads were injected. 

Schramm G, Mohrs K, Wodrich M, et al IPSE/al, a glycoprotein from Schistosoma mansoni eggs, induces IgE-dependent, antigen-independent IL-4 production by murine basophils in vivo. J Immunol 2007 178 6023-6027. 

Weiss, J.B. and Strand, M. (1985) Characterization of developmentally regulated epitopes of Schistosoma mansoni egg glycoprotein antigens. Journal of Immunology 135, 1421-1429. 

Sabin EA, Pearce EJ. Early IL-4 production by non-CD4 cells at the site of antigen deposition predicts the development of a T helper 2 cell response to Schistosoma mansoni eggs. J Immuno 1995 155 4844-53. 

Dunne, D.W., Bickle, Q.D., Butterworth, A.E. and Richardson, B.A. (1987) The blocking of human antibody-dependent, eosinophil-mediated killing of Schistosoma mansoni schistosomula by monoclonal antibodies which cross-react with a polysaccharide-containing egg antigen. Parasitology 94, 269-280. 

Purification of mammalian serum haptoglobin Purification of Schistosoma mansoni soluble egg antigens... 

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