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Gene therapy for

Gene therapy for rectification of defects in the enzymes of the urea cycle is an area of active investigation. Encouraging preliminary results have been obtained, for example, in animal models using an adenoviral vector to treat citrullinemia. [Pg.248]

Patejunas G et al Evaluation of gene therapy for citrullinaemia using murine and bovine models. J Inherit Metab Dis 1998 21 138. [Pg.248]

Kitamoto S, Egashira K. Anti-monocyte chemoattractant protein-1 gene therapy for cardiovascular diseases. Expert Rev Cardiovasc Ther 2003 1(3) 393 KX). [Pg.232]

Fig. 1.11 Applications of LDHs as (A) non-viral vector in gene therapy for transfection of DNA to the cell nucleus, and (B) as matrix for enzymes immobilization in the development of biosensors. Fig. 1.11 Applications of LDHs as (A) non-viral vector in gene therapy for transfection of DNA to the cell nucleus, and (B) as matrix for enzymes immobilization in the development of biosensors.
Hershfield MS (1995) PEG-ADA an alternative to haploidentical bone marrow transplantation and an adjunct to gene therapy for adenosine deaminase deficiency. Hum Mutat 5 107-112... [Pg.138]

Docherty, K. 1997. Gene therapy for diabetes mellitus. Clinical Science 92(4), 321-330. [Pg.326]

Buchschacher, G. and Wong-Staal, F. 2001. Approaches to gene therapy for human immunodeficiency virus infection. Human Gene Therapy 12(9), 1013-1019. [Pg.461]

Demeterco, C. and Levine, F. 2001. Gene therapy for diabetes. Frontiers in Bioscience 6, D175-D191. [Pg.461]

Furlan, R., Butti, E., Pluchino, S., and Martino, G. 2004. Gene therapy for autoimmune diseases. Current Opinion in Molecular Therapeutics 6(5), 525-536. [Pg.461]

Yechoor, V and Chan, L. 2005. Gene therapy progress and prospects gene therapy for diabetes mellitus. Gene Therapy 12(2), 101-107. [Pg.462]

Wang, M. S., Fang, G., Culver, D. G., Davis, A A., Rich, M. M., and Glass, J. D. The Wlds protein protects against axonal degeneration a model of gene therapy for peripheral neuropathy. Ann. Neurol. 50 773-779, 2001. [Pg.526]

Gene therapy for this metabolic defect may become available within the next few years. In vitro studies have demonstrated the feasibility of retroviral-mediated gene transfer of both the El-a and E2 subunits of the branched-chain decarboxylase complex [16,18],... [Pg.672]

The possibility of gene therapy for these disorders is a subject of intense scrutiny [38]. An adenoviral vector containing a cDNA for the OTC gene has been given to mice with a congenital deficiency of OTC. The result was... [Pg.680]

Basic Principles for Preclinical Safety Evaluation of Cellular and Gene Therapies. For biotechnology-derived products in general... [Pg.66]

Exhibit 11.6 describes a recent gene therapy trial that resulted in unexpected outcomes, which the regulatory authorities have to consider. A recent report of gene therapy for treatment of Alzheimer s disease is also included. [Pg.367]

Friedmann T, Roblin R. Gene therapy for human genetic disease. Science 1972 175(25) 949-955. [Pg.269]

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. LM02-associated clonal T cell proliferation in two patients after gene therapy for SCID-Xl. Science 2003 302(5644) 415 19. [Pg.270]

Yoshida J, Mizuno M. Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma. J Neurooncol 2003 65(3) 261-267. [Pg.308]

Many diseases, such as hereditary metabolic defects and tumors, can still not be adequately treated. About 10 years ago, projects were therefore initiated that aimed to treat diseases of this type by transferring genes into the affected cells (gene therapy). The illustration combines conceivable and already implemented approaches to gene therapy for metabolic defects (left) and tumors (right). None of these procedures has yet become established in clinical practice. [Pg.264]

McCormack MP, Rabbitts TH. Mechanisms of disease activation of the T-cell oncogene LM02 after gene therapy for X-linked severe combined immimodeficiency. N Engl J Med 2004 350 913-22. [Pg.76]

Zhang YC, Atkinson MA. Gene therapy for type 1 diabetes metabolism, immunity, islet cell preservation, and regeneration. Curr Opin Endocrinol Diabetes 2004 11 91-7. [Pg.76]

Chan L, Fujimiya M, Kojima H. In vivo gene therapy for diabetes meUitus. Trends Mol Med 2003 9 430-5. [Pg.76]

Anderson DG, Peng W, AMnc A, Hossain N, Kohn A, Padera R, Langer R, SawicM JA (2004) A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sd USA 101 16028-16033... [Pg.16]

Roth J A, Swisher SG, Merritt J A, etal. Gene therapy for non-small cell lung cancer a preliminary report of a phase I trial of adenoviral p53 gene replacement. Semin Oncol 1998 25 33-37. [Pg.358]

Trials of gene therapy for inherited conditions have captured the most... [Pg.96]


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See also in sourсe #XX -- [ Pg.693 , Pg.694 ]

See also in sourсe #XX -- [ Pg.693 ]

See also in sourсe #XX -- [ Pg.158 ]




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Adeno-associated viral vectors for gene therapy

Adeno-associated virus mediated gene therapy for vascular retinopathies

Adenoviral vectors for gene therapy

Adenovirus vectors for gene therapy

Application of gene therapy for specific kidney diseases

Characterization of Adenovirus Structural Proteins for Gene Therapy

Disease targets for gene therapy

Endogenous Polymers as Biomaterials for Nanoparticulate Gene Therapy

Gene Therapy for Cancer Treatment

Gene Therapy for Retinal Disease

Gene and Cell-based Therapies for Cardiovascular Disease

Gene therapy

Gene therapy for cardiovascular applications

Gene therapy for kidney diseases

Gene therapy for lysosomal storage disorders

Gene therapy strategy for

Gene therapy vectors for

Gene therapy, for cystic fibrosis

Herpes simplex virus type 1 thymidine kinase a target for gene-therapy based anticancer drugs

Pluronic Block Copolymers for Gene Therapy

Potential Disease Targets for Gene Therapy

San Raffaele Telethon Institute for Gene Therapy

Suicide gene therapy for cancer

Viral vectors for gene therapy

Viruses vectors for gene therapy

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