Polymer libraries

The Polymer Library (www.polymerlibrary.com) is the world s most comprehensive collection of information on... 

Green JJ, Langer R, Anderson DG (2008) A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res 41 749-759... 

A comprehensive References and Abstracts section, resulting from a search of the Rapra Polymer Library database. The format of the abstracts is outlined in the sample record below. 

Therefore, polymer libraries, in combination with high-throughput screening techniques, are highly useful tools for the evaluation of (quantitative) structure-property relationships and/or the identification of hits of certain desired properties of the evaluated materials. These tools help researchers to understand their research problems more thoroughly by, e.g., finding optimal process conditions or product performance within a reduced amount of time and/or experimental effort. 

Within the following sections we will give a brief overview of the available high-throughput methods for the preparation and screening of polymer libraries and then focus our discussion on well recognized literature examples of polymer libraries. 

Polymer libraries are generally not prepared for their own sake, but rather in order to explore some key property of the investigated materials. The technique used to prepare a given polymer library is often dictated by the method(s) to be used to screen or characterize the library compositions for the key properties of interest. 

Fig. 4 Illustration of (a) Chemspeed automated synthesizer and (b) Symyx batch polymerization system for synthesis of discrete polymer libraries. Reprinted with permission from [90], (Copyright 2007 Taylor Francis Group, http //www.informaworld.com)...

In recent years, many examples of polymer libraries applying high-throughput experimentation concepts for the fast and reliable determination of structure-property relationships were reported in the literature. 

Lynn DM, Anderson DG, Putnam D, Langer R (2001) Accelerated discovery of synthetic transfection vectors parallel synthesis and screening of a degradable polymer library. J Am Chem Soc 123 8155-8156... 

Anderson DG, Peng W, AMnc A, Hossain N, Kohn A, Padera R, Langer R, SawicM JA (2004) A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sd USA 101 16028-16033... 

Keywords Automated parallel synthesis Block copolymers experimentation Polymer libraries Random copolymers... 

In this chapter, we will focus on the use of CLP techniques for the synthesis of systematic copolymer libraries using high-throughput approaches. Prior to that, automated parallel optimization reactions that have been performed for different CLP techniques will be discussed. At the end of this chapter there will be a highlight on the latest synthetic approaches to synthesize well-defined polymer libraries. 

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