Encapsulation gelatin capsules

Dronabinol. Marinol ( ii7R-/n7 j )-6i7,7,8,I0i7-tetrahydro-6,6,9-trimethyl-3-pentyl-6JT-diben2o(B,D) pyran-I-ol is the principal psychoactive substance present in Cannabis sativa F., ie, marijuana. It is a controlled substance, formulated in sesame oil and encapsulated in soft gelatin capsules for oral adrninistration. 

This section addresses the design of immediate-re-lease powder formulations for hard gelatin capsules. In general, powder formulations for encapsulation should be developed in consideration of the particular filling principle involved. The requirements imposed on the formulation by the filling process, such as lubricity, compressibility and/or compactibility, and fluidity can vary between machine types. Furthermore, the... 

G Reier, R Cohn, S Rock, F. Wagenblast. Evaluation of factors affecting the encapsulation of powders in hard gelatin capsules I. Semi-automatic capsule machines. J Pharm Sci 57 660-666, 1968. 

The drug dissolution profiles from capsules have been documented to change with time due to changes in the gelatin capsule shell properties, interaction between gelatin and an encapsulated ingredient such as anionic compounds (e.g., substituted benzoic and sulfonic acid dyes), and compounds with keto groups. The... 

This test may also be carried out by an alternative procedure in which the reducing reagent is prepared in encapsulated form. Mix togefiier thorou y 10 g of sodium dithionite, 6 g of disodium tetraborate and 25 g of sodium bicarbonate pack the mixture into gelatine capsules (gauge 0) to produce about 40 capsules. To carry out file test, tip the contents of 1 capsule into 10 ml of urine or stomach contents, and shake to dissolve. A blue colour, due to the... 

VegiCap Soft capsules are an alternative patent-protected Softgels that deliver all of the key attributes of traditional soft gelatin capsules without gelatin. They are made using a modification of the Scherer rotary die encapsulation machines. 

Schaltenbrand R, Huber R, Cotoraci CA, Mascher H, Potthast H, Hole U. Bioequivalence between omeprazole MUPS 20 mg as tablet and omeprazole MUPS 20 mg as tablet encapsulated in a hard gelatine capsule. Int J Clin Pharmacol Ther 2001 39(10) 453-9. 

The manufacture and formulation of hard gelatin capsules has not been the subject of as much research as tabletting, partly because encapsulation unlike compression is not a science shared by many other disciplines. Nevertheless, there has been important work performed on this dosage form, and much of it is captured in Hard Capsules Development and Technology (Ridgway 1987). 

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