Stability soft gelatin capsules

The formulation for soft gelatin capsules involves liquid rather than powder technology. Materials are generally formulated to produce the smallest possible capsule consistent with maximum stability, therapeutic effectiveness, and manufacture efficiency [3],... 

Calcitriol must be protected from air and light. The drug substance exhibits good stability when stored at -15°C to -25°C in an argon atmosphere. The material is stable at room temperature when dissolved in a vegetable oil derivative, containing antioxidants, such as is used in calcitriol soft gelatin capsules (19). 

In this chapter, the uses of cosolvents are discussed with some speciLc limitations. The discussion is limited to the cosolvent effects on solubility and stability, their use in parenteral products. For information on the use of cosolvents in other dosage forms such as soft gelatin capsules, the reader is referred to the speciLc chapter in this book on the topic. 

In general, therefore, it is recommended that soft gelatin capsules be stored in a cool, dry place for maximum stability. 

Figure 16 Stabilization of nifedipine in soft gelatine capsules using Acid Yellow (E 105). (O) dye in capsule shell, ( ) dye in capsule shell and filling, (3) dye in capsule filling,...

Soft gelatin capsules are a more expensive dosage form than either tablets or capsules, so they tend to be considered when they can offer a major benefit to the formulator. Justifications for their use include improved content uniformity, safety, improved stability and improved bioavailability. 

Uses Emulsifier, consistency agent, opacifier for foods, cosmetics, pharmaceuticals, veterinary prods. thickener for pharmaceutical ointments, creams, and lotions excipient, vehicle for dermal and oral dosage forms stabilizer in soft gelatin capsule oily formulations... 

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