Gastrointestinal disturbances tract

Adverse effects of copper deficiency can be documented in terrestrial plants and invertebrates, poultry, small laboratory animals, livestock — especially ruminants — and humans. Data are scarce or missing on copper deficiency effects in aquatic plants and animals and in avian and mammalian wildlife. Copper deficiency in sheep, the most sensitive ruminant mammal, is associated with depressed growth, bone disorders, depigmentation of hair or wool, abnormal wool growth, fetal death and resorption, depressed estrous, heart failure, cardiovascular defects, gastrointestinal disturbances, swayback, pathologic lesions, and degeneration of the motor tracts of the spinal cord (NAS 1977). 

Indometacin, which is a non-steroidal anti-inflammatory drug, inhibits the enzyme cyclo-oxygenase implicated in inflammatory reactions. Indometacin is more effective as an anti-inflammatory agent than ibuprofen and tends to have a higher side-effect profile, including headache, diarrhoea and gastrointestinal disturbances. Rectal administration reduces but does not prevent gastrointestinal tract disturbances. 

In humans, the dust is irritating to the eyes and the respiratory tract it causes dermatitis in some individuals. Large oral doses cause gastrointestinal disturbances. ... 

Niclosamide is a salicylamide derivative. Its mechanism of action could be based on inhibition of oxidative phosphorylation or on its ATPase stimulating action. The scolices and segments, but not segments of the ova, are rapidly killed. Niclosamide is minimally absorbed from the gastrointestinal tract and excreted, mostly unchanged, in the faeces. It is generally well tolerated with occasional gastrointestinal disturbances. Skin eruptions have been reported. 

Benzoic acid derivatives Repaglinide (Prandin) Nateglinide (Starlix) Similar to the sulfonylureas Hypoglycemia bronchitis upper respiratory tract infections joint and back pain gastrointestinal disturbances headache... 

Toxicity Dalapon is moderately toxic to humans. Skin and inhalation exposure could be of significance to dalapon production workers, pesticide applicators, and some agricultural workers. Effects of acute exposure include absence of appetite, slowed heartbeat, skin irritation, eye irritation (e.g., conjunctivitis or corneal damage), gastrointestinal disturbances (e.g., vomiting or diarrhea), tiredness, pain, and irritation of the respiratory tract. Dalapon is an acid that may cause corrosive... 

Definitive information regarding the acute toxicity of di-N-octylphthalate is not available. An estimated lethal oral dose in humans is between 0.5 and 15gkg, or between 1 oz equivalent to 29.6 mis and 1 qt equivalent to 0.96 liters in a 70 kg adult. Compounds that are structurally similar to di-N-oct-ylphthalate are known to irritate mucous membranes resulting in irritation of the eyes, throat, and upper respiratory tract passages and in gastrointestinal disturbances. There is evidence that some phthalates, such as di-s-octylphthalate, may be reproductive and developmental toxicants. Generally, the acute oral toxicity of alkylphthalates is low and the acute oral toxicity decreases as molecular weight increases. 

Chronic exposure can cause bronchial irritation, gastrointestinal disturbances, rash, possible sensitization, dental erosion, and jaw necroses. Inhalation can cause upper respiratory tract effects and possible dyspenea and hemoptysis. 

HEALTH SYMPTOMS Inhalation (irritates respiratory tract) skin (mild irritation) eyes (severe irritation, comeal damage) ingestion (gastrointestinal disturbances, tumors of the liver). 

HUMAN HEALTH RISKS EPA Group D not classifiable as to human carcinogenity Acute Risks irritation to eyes, mucous membranes, skin and respiratory tract Chronic Risks. headaches dizziness nausea gastrointestinal disturbances liver and kidney damage. 

ACUTE HEALTH RISKS irritation of skin, eyes, and upper respiratory tract central nervous system depression pulmonary edema gastrointestinal disturbances nausea headaches vomiting kidney damage damage to the liver. 

ACUTE HEALTH RISKS irritation of eyes, skin, and throat irritation to mueous membranes and upper respiratory tract headache nausea fatigue numb limbs gastrointestinal disturbances central nervous system effects liver damage. 

HEALTH SYMPTOMS inhalation (irritates respiratory tract, chronic pulmonary fibrosis (lung scarring)) skin contact (no adverse effects expected) eye contact (no adverse effects expected but dust may cause mechanical irritation) ingestion (gastrointestinal disturbances caused by extremely large oral doses, stomach granuloma). 

ACUTE HEALTH RISKS may cause irritation to respiratory tract may produce gastrointestinal disturbances dust may cause mechanical irritation to eyes. 

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