Causative mechanisms

Acute effects of overexposure are as follows. Exposure to dust may cause mechanical irritation of the eye. PPS is essentially nonirritating to the skin, although freshly molded material may occasionally cause dermatitis. Inhalation of PPS dust may cause mechanical irritation to mucous membranes of nose, throat, and upper respiratory tract. 

Many of the variations developed to make pressure sensors and accelerometers for a wide variety of appHcations have been reviewed (5). These sensors can be made in very large batches using photoHthographic techniques that keep unit manufacturing costs low and ensure part-to-part uniformity. A pressure differential across these thin diaphragms causes mechanical deformation that can be monitored in several ways piezoresistors implanted on the diaphragm are one way changes in electrical capacitance are another. 

Fretting Corrosion This attack occurs when metals shde over each other and cause mechanical damage to one or both. In such a case, frictional heat oxidizes the metal and this oxide then wears away or the mechanical removal of protective oxides results in exposure of fresh surface for corrosive attack. Fretting corrosion is minimized by using harder materials, minimiziug friction (via lubrication), or designing equipment so that no relative movement of parts takes place. 

The cathodic protection of pipelines is best monitored by an intensive measurement technique according to Section 3.7, by an off potential survey eveiy 3 years and by remote monitoring of pipe/soil potentials. After installation of parallel pipelines, it can be ascertained by intensive measurements whether new damage of the pipe coating has occurred. These measurements provide evidence of possible external actions that can cause mechanical damage. 

The defect question delineates solid behavior from liquid behavior. In liquid deformation, there is no fundamental need for an unusual deformation mechanism to explain the observed shock deformation. There may be superficial, macroscopic similarities between the shock deformation of solids and fluids, but the fundamental deformation questions differ in the two cases. Fluids may, in fact, be subjected to intense transient viscous shear stresses that can cause mechanically induced defects, but first-order behaviors do not require defects to provide a fundamental basis for interpretation of mechanical response data. 

Occurrence (the likelihood that a specific cause/mechanism will occur in the range 1 to 10, with 10 being almost inevitable and 1 being unlikely)... 

Vibration of the compressor, pipe, and vessels, even to the extreme of causing mechanical and foundation failure. 

It is important to investigate possible situations of harmful resonance. Although all pipes and pipe-volume combinations will resonate, it is necessary to investigate only the cases that might cause mechanical problems. This refers to a frequency that will given a objectionable beat frequency or to a length of pipe that is tuned to a stimulating frequency. 

The grounding conductors must be capable of carrying maximum earth fault current without overheating or causing mechanical damage. 

At higher flow rates cavitation is a serious degradation mechanism, where vapor bubbles created by pressure fluctuations brought about by the flow of liquid past the surface collapse on the metal surface with tremendous force. This damages any protective oxide which may be present, leading to pitting corrosion. It also causes mechanical damage to the metal. 

These fillers are soft and do not dramatically affect mechanical properties. PTFE loadings commonly range from 5 to 20% the others are usually 5% or less. Higher loadings can cause mechanical degradation. 

Chung KF, Widdicombe J, Boushey H (2003) Cough causes, mechanisms and therapy. Blackwell, Oxford, UK... 

Many diseases are known to be caused by the intracellular retention of mutant proteins or by the impairment of components of the secretory pathway [4]. The disease-causing mechanisms include ... 

The high active tension and/or high active strain that occurs in muscle during lengthening contractions is believed to cause mechanical disruption of muscle fibers and connective tissue (Armstrong, 1984 Lieber and Friden, 1993). Activa-... 

Exposure to fiime and the precipitated silica (amorphous silica) causes fatal bronchial response as these are respirable. Repeated exposure dries the skin and causes mechanical irritation to eyes. Sol-gel silica, as an alternative to this, ceases the floating problem and avoids unnecessary contamination. 

Damage to the host may arise in two ways. First, multiplication of the microorganisms may cause mechanical damage to the tissue cells through interference with the normal cell metabolism, as seen in viral and some bacterial infections. Second, a toxin associated with the microorganism may adversely affect the tissues or organs of the host. Two types of toxins, called exotoxins and endotoxins, are associated with bacteria. 

Flow instabilities are undesirable in boiling, condensing, and other two-phase flow processes for several reasons. Sustained flow oscillations may cause forced mechanical vibration of components or system control problems. Flow oscillations affect the local heat transfer characteristics and may induce boiling crisis (see Sec. 5.4.8). Flow stability becomes of particular importance in water-cooled and watermoderated nuclear reactors and steam generators. It can disturb control systems, or cause mechanical damage. Thus, the designer of such equipment must be able to predict the threshold of flow instability in order to design around it or compensate for it. 

PN can cause mechanical or technical (e.g., malfunctions in delivery system and catheter-related complications), infectious (e.g., colonization of the catheter or direct microbial invasion of the skin), metabolic (Table 60-3), and nutritional complications. 

The mechanism most commonly invoked to explain the association of infection with autoimmune disease is molecular mimicry that is, the concept that antigens (or more properly, epitopes) of the microorganism closely resemble self-antigens.50 The induction of an immune response to the microbial antigen thus results in cross-reactivity with selfantigens and the induction of autoimmunity. Although epitope specific cross-reactivity has been shown in some animal models,48,51 53 molecular mimicry is clearly demonstrated to be the causative mechanism in few, if any, human diseases.3 54,55... 

Degradation of the By causing mechanical damage or physical or cyber disruption, for purposes of causing severe direct or indirect economic damages... 

In this kind of pseudorotaxanes, rotaxanes, and catenanes, the stability of a specific (supra)molecu-lar structure is a result, at least in part, of the CT interaction. In order to cause mechanical move ments, such a CT interaction has to be destroyed. 

Scheme 11.1 The most common substructures causing mechanism-based inactivation of cytochrome P450s ...

The test programs which are summarized in detail in this section were usually not planned to test a causative mechanism. Rather, they were carried out to determine the effect of variables which were thought to be important in initiating the event. The results were normally reported only as explosions achieved or, conversely, not achieved. 

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