Gastrointestinal disease cancers

Lewin KJ, Ranchod M, Dorfman RF (1978) Lymphomas of the gastrointestinal tract a study of 117 cases presenting with gastrointestinal disease. Cancer 42 693-707... 

A recent patent application from Roche [352] described a 2-amino-benzothiazole series. Roche claimed that compound (605) exhibited an IC50 value of 0.73 uM at CBi, and showed in excess of 10-fold selectivity over the CB2 receptor. The compounds were described as being of potential use in the treatment of a range of diseases, including CNS and psychiatric disorders, type-2 diabetes, gastrointestinal diseases, cardiovascular disorders, infertility disorders, inflammation, cancer, atherosclerosis, cerebral vascular incidents and cranial trauma. 

Serum cancer antigen 125 (CA-125) is the most extensively evaluated tumor marker for ovarian cancer. Unfortunately, the CA-125 determination is non-specific, and elevated levels can be associated with a number of other gynecologic and gastrointestinal diseases. CA-125 levels in a woman without ovarian cancer, though, are static or tend to decrease over time, whereas levels associated with malignancy will continue to rise.10 Since CA-125 is a non-specific marker, there is no standard recommendation for routine screening for prevention of ovarian cancer. 

Those which are produced by fungal microbes are linked directly to animal and human health as being the products of fungal growth. These mycotoxins are causative agents of gastrointestinal disturbances, cancer, reproductive failure, renal and nervous diseases, and abnormal tissue perfusion. 

Colorectal cancer is one of the most common potentially lethal gastrointestinal diseases encountered in clinical practice and can be curable with proper management. In the United States in 1993, there were an estimated 152000 new cases of colorectal cancer and 57000 deaths from this disease [46]. Approximately 30-40% of patients with colorectal cancers are not candidates for aggressive surgical therapy because of distant metastases, extensive local tumor infiltration, poor general condition or refusal of the patient to undergo surgery. These are the patients who require... 

The cancers that exhibited a significant inverse relationship between green tea consumption and disease incidence are colon, rectal, pancreatic, stomach, ovarian, and gastrointestinal tract cancers. In most of the cases, the epidemiological data were... 

Because colorectal cancer develops through two differently pathological pathways, Lanza et al. used miRNA microarray chip to investigate different miRNA profiles of colorectal cancer between two differently pathological pathways. They reported the presence of 27 differently expressed gene, including 8 miRNAs and showed that their functions were most frequently associated with cell cycle, DNA replication, recombination, repair, gastrointestinal disease, and immune response [60]. 

Traditional use Inflorescences are used as a vermifuge, carminative, and choleretic, to heal wounds, and to treat intoxication due to lung tuberculosis, fevers, gastrointestinal diseases, and low acidity (Khalmatov et al. 1984). An infusion of the inflorescences is used in Russian folk medicine to increase appetite, bile and sweat production, blood pressure, and decrease heart rates. The infusion is also used as an antipyretic, antispasmodic, anti-inflammatory, analgesic, vermifuge, insecticide, and anti-microbial, and to heal wounds. In the folk medicine of North Caucasus a decoction of the herb is used to treat headaches, and is used externally to treat rheumatism. A decoction of the inflorescences is used to treat skin cancer (Altimishev 1991). 

Gastrointestinal disease. The du Pont data indicate an increased risk of cancer of the colon among employees exposed to acrylonitrile. In addition, the animal studies show possible tumor production in the stomachs of the rats in the ingestion study. 

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