British Pharmacological Society

Nazzaro, Jules M., Thomas F. Seeger, and Eliot L. Gardner. 1980. "Naloxone Blocks Phencyclidine s Dose-Dependent Effects on Direct Brain Reward Thresholds." Proceedings cf World Conference on Clinical Pharmacology and Therapeutics. London British Pharmacological Society. 

Here we investigate the neuroprotective potential of BEO in vivo by using an experimental model of focal brain ischemia in rats. Moreover, we evaluate whether neuroprotection is associated with altered levels of excitatory neurotransmitters and with a modulation of PI3-K/Akt pathway in the ischemic cortex. Our results indicate that BEO indeed protects against ischemic injury in an in vivo model of permanent focal brain ischemia in rat and that neuroprotection is associated with reduced excitatory amino acid efflux induced by MCAo in the ischemic cortex and elevation ofp-Akt and phospho-GSK-3/3 (p-GSK-3/3) levels in the ischemic penumbra. A preliminary account of this in vivo study has been communicated to the British Pharmacologic Society (Morrone et al., 2006). 

In another survey conducted by the clinical section of the British Pharmacological Society over a one-year period from 1986 to 1987, 8163 healthy volunteers received drugs for research purposes.Potentially life-threatening adverse effects were reported in 0-04% and moderately severe adverse effects in 0-55%, with no lasting sequelae. The three severe reactions were skin irritation and rash requiring hospitalisation, anaphylactic shock after an oral vaccine, and perforation of a duodenal ulcer after multiple-dose non-steroidal anti-inflammatory drug all made a complete recovery. The results were similar to those reported in the earlier ABPI survey and the authors concluded that the risk involved in these studies is very small... 

Butler WH, Magos L. 1970. Liver damage and excretion of bivalent sulfur after exposure to carbon disulfide [abstract], British Pharmacological Society 40 171-172. 

Data from American Psychiatric Association. Diagnostic and Statistical Manuai of Mental Disorders, 4th edv text revision. Washington, DC American Psychiatric Association, 2000 429-484 and Baldwin DS, Anderson iMr Nutt DJr et al. Evidence-based guidelines hr the pharmacological treatment of anxiety disorders Recommendations from the British Society for Psychopharmacology. J Psychopharmacology 2005 19 567-596. 

British Medical Association and Pharmaceutical Society of Great Britain 1963, British National Formulary, Alternative Edition, based on a pharmacological classification edn, British Medical Association and Pharmaceutical Society of Great Britain, London. 

Reidenberg M M 1999 Clinical pharmacology the scientific basis of therapeutics. Clinical Pharmacology and Therapeutics 66 2-8 Walley T 1995 Drugs, money and society. British Journal of Clinical Pharmacology 39 343-345... 

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