Glucose deprivation

Harris CS, Lambert J, Saleem A, et al (2008) Antidiabetic activity of extracts from needle, bark, and cone of Picea glauca organ-specific protection from glucose toxicity and glucose deprivation. Pharm Biol 46 126-134... 

Cheng B, McMahon DG, Mattson MP Modulation of calcium current, intracellular calcium levels and cell survival by glucose deprivation and growth factors in hippocampal neurons. Brain Res 607 275-285, 1993 Cheng CHK, Costall B, Kelly ME, et al Actions of 5-hydroxytryptophan to inhibit and disinhibit mouse behaviour in the hght dark test. Eur J Pharmacol 255 39-49, 1994... 

The selected 4-bismethanesulfonylamino-2-phenyl-l,2,4-triazolo[4,3-a] quinoxalin-l-one, which shows high hA3 affinity (13, K. = 5.5 nM) and selectivity versus hA1( hA2A (both selectivity ratios > 1,800) and hA2B (cAMP assay, IC50 > 10,000 nM) receptors, recently showed protective effect on cerebral ischemia induced by oxygen and glucose deprivation (Colotta et al. 2008). 

Goldberg M. P. and Choi D. W. (1993). Combined oxygen and glucose deprivation in cortical cell culture Calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13 3510-3524. 

The main finding of the present manuscript is that pharmacological inhibition of the GPx activity, reduces the extent of ischemic damage produced by transient MCAo in the rat brain and limits the irreversible functional derangement of field potentials in corticostriatal slices caused by a prolonged (12 min) oxygen-glucose deprivation. 

AMPK is activated during various physiological or pathophysiological conditions. During cellular stresses, such as glucose deprivation, ischemia, hypoxia, and... 

Iijima, T., Mishima, T., Akagawa, K., Iwao, Y. Mitochondrial hyperpolarization after transient oxygen-glucose deprivation and subsequent apoptosis in cultured rat hippocampal neurons. Brain Res. 2003, 993 140-145. 

Bialik S, Cryns VL, Drinric A, Miyata S, Wollowick AL, Srinivasan A, et al. The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes. Circ Res 1999 85 403-414. 

Mattson, M.P., Zhu, H., Yu, J., and Kindy, M.S., 2000b, Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture Involvement of perturbed calcium homeostasis. J. Neurosci. 20 1358-1364. 

Zhou, J. Fu, Y Tang, X. C. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport, 2001, 12 2073-2077. 

Almeida A, Delgado-Esteban M, Bolanos JP, Medina JM (2002) Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. J Neurochem 81 207-217... 

Cater HL, Benham CD, Sundstrom LE (2001) Neuroprotective role of monocarboxylate transport during glucose deprivation in slice cultures of rat hippocampus. J Physiol 531 459-466... 

Nijjar, M.S. 1993. Effects of domoate, glutamate and glucose deprivation on calcium uptake by rat brain tissue in vitro. Biochem Pharmacol. 46, 131-138. 

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