Fibroblast-associated carcinoma

Olumi, A. F., Grossfeld, G. D., Hayward, S. W., Carroll, P. R., Usty, T. D., and Cunha, G. R. 1999. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 59 5002-5011. 

Fibromas are composed mostly of fibroblasts and spindle cells and abundant collagen contents. Fibromas are not hormonally active. Fifteen percent of fibromas are associated with ascites (Fig. 9.32), and in 1% pleural fluid is also found [83]. This triad of an ovarian fibroma, ascites and pleural effusion constitutes the benign Meigs syndrome, which can be associated with elevated Ca-125 levels [84]. In basal cell nevus syndrome, numerous basal cell carcinomas are associated with abnormalities of bones, eyes, brain, and tumors, including ovarian bilateral fibromas [85]. 

TS possesses multiple cell attachment sites, which enable it to associate with a variety of cells (endothelial cells, smooth muscle cells, some fibroblasts, kera-tinocytes, neurons, squamous carcinoma cells, malignant fibrosarcoma cells, melanoma cells), and with fibrinogen, fibronectin, laminin, plasminogen, plasminogen activator, collagen, calcium ions and glycos-aminoglycans. Four sites have been implicated in cell... 

The association between exposure to asbestos dust and the development of lung carcinoma and diffuse mesotheliomata of the pleura and peritoneum has been well documented (Selikoff and Lee 1978). Both crocidolite and amosite were capable of augmenting the oncogenic effect of benzo[a]-pyrene. This putative synergistic effect was evident when fibres and chemicals were added to cultures of murine fibroblast cultures as simple mixtures and when benzo[a]pyrene was adsorbed to the surface of the fibres (Brown et al. 1983). 

Following the early observation of Klenk and Yamakawa and their associates, the presence of sialic acid residues at the surface of numerous cells was established, either by action of neuraminidase followed by determination of the cell electrophoretic mobility or by determination of the sialic acid released. For example, sialic acid residues were detected at the surface of EMich ascites tumor cells (Wallach and Eylar, 1961 Cook et aL, 1962), hamster kidney fibroblasts transformed by polyoma virus (Forrester et aL, 1964), squamous epithelial cells (Berwick and Coman, 1962), solid and ascites sarcoma cells (Cook et aL, 1963 Wallach and de Perez Esandi, 1964), normal and malignant rat liver cells (Kalant et aL, 1964), cells from human bronchial carcinoma, cells from rat myeloma, HeLa cells, and L-strain mouse fibroblasts (Fuhrmann etaL, 1962). 

---