Feverfew Tanacetum

Heptinstall S, Awang DVS, Dawson BA, Kindack D, Knight DW, May J. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (1.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products. J Pharm Pharmacol 44 391-395, 1992. 

Feverfew (Tanacetum parthenium). Reprinted with permission from Sturdivant and Blakely. (1999). Medicinal Herbs in the Garden, Field, and Marketplace. Friday Flarbor, WA San Juan Naturals. Illustration by Peggy Sue McRae. 

English marigold Caienduia officinalis), fennel, yarrow Achillea millefolium), dandelion, angelica, cilantro, feverfew Tanacetum parthenium), tansy Tanacetum vulgare)... 

Ephedra (Ephedra sinica)/Ma Huang Evening Primrose Oil Oenothera biennis) Feverfew Tanacetum parthenium)... 

Feverfew (Tanacetum parthenium) is commonly used for the treatment of migraine headaches, arthritis, and various type of allergies. This herb is thought to exert its pharmacological activity by... 

More than 11,000 Sesquiterpenes have been isolated from natural sources [3]. Feverfew (Tanacetum parthenium (L.) Sch. Bip.,. Compositae) is a common herb utilized for fever, arthritis and migraine. The leaves of feverfew contain large amounts of sesquiterpene lactones. The chloroform extracts of fresh leaves and a commercial leaf product show dose-dependent inhibiting the production of throboxane B2 (TXB2) and leukotriene B4 (LTB4) in rat and human leukocytes. Sesquiterpene lactones isolated from the leaves of feverfew, such as parthenolide and tanaparthin-a-peroxide, demonstrate potent dual inhibitions of COX and LOX pathways with IC50 for COX at 6 17 pg/ml, and for LOX at 12 17 pg/ml, respectively [135],... 

HAUSEN, B.M., Occupational contact allergy to feverfew Tanacetum parthenium (L.) Schultz-Bip. Asteraceae., Derm. Beruf. Umwelt., 1981,29,18-21. 

Angei s trumpet Datura suaveolens Feverfew Tanacetum parthenium... 

Feverfew. Tanacetum parthenium (L.) Schultz Bip. is an herb that was used in antiquity to reduce fever and pain. The literature is replete with anecdotal evidence of the usefulness uf the herb, and recent clinical studies have added more support. Feverfew is a member of the aster/dai.sy family. The plant tissues have a pungent smell and very bitter taste. The medicinal principle of feverfew is concentrated in hairy trichomes on the chiysanthemum-like leaves.The plant displays clusters uf daisy-like flowers with yellow centers and radiating white florets. Recent uses uf feverfew are for migraine and arthritis, although the indication for arthritis is disputable. The anecdotal evidence that an herb could successfully treat a condition such as migraine headache naturally begged for some seientifle proof. 

Makhej a AN, B ailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins LeukotMed 1982 8 653-660. 

Exposure to Asteraceous plants may also result in the development of contact dermatitis. One Serbian study has indicated that it is not unusual to detect sensitization to chamomile (Chamomilla recutita), arnica (Arnica montana), tansy (Tanacetum vulgare), and feverfew (Tanacetum parthenium) (Jovanovic et al., 2004). Contact dermatitis, along with asthma and rhinitis, may also accompany occupational exposure to chamomile (Rudzki et al., 2003) and contact dermatitis to feverfew (Hausen, 1981). Similarly, chamomile in cosmetic products can also be a cause of dermatitis (Paulsen, 2002 Rycroft, 2003). Because chamomile-containing products, particularly in shampoos and other OTC products, are so widespread, the linkage to these types of adverse events are likely underreported. Also, use of royal jelly, a thick mixture of honey, pollen, and their allergens, has been associated with several cases of bronchospasm, and topical application of concentrated forms of bee pollen (propalis) to contact dermatitis (Perharic, 1993). Milk thistle has also been known to cause urticaria (De Smet, 2004). 

Zhou JZ, Kou X, Stevenson D. Rapid extraction and high performance liquid chromatographic determination of parthenolide in feverfew (Tanacetum parthenium). J Agric Food Chem 1999 47 1018-1022. 

Heptinstall S, Awang DVC, Dawson BA, et al. Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium). Estimation of Commercial and Authenticated Feverfew Products. J Pharm Pharmacol 1992 44 391-5. 

Awang DVC, Dawson BA, Kindack DG, Heptinstall S. Parthenolide content of feverfew [ Tanacetum parthenium (L.) Schultz-Bip.] assessed by HPLC and H-NMR spectroscopy. JNatProd 1991 54 1516-21. 

Dolman DM, Knight DW, Salan U, Toplis D. A quantitiative method for the estimation of parthenolide and other sesquiterpene lactones containing alphamethylenebutyrolactone functions present in feverfew, Tanacetum parthenium. Phytochem Anal 1992 3 26-31. 

Palevitch D, Earon G, Carasso R. Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine a double-blind placebo-controlled study. Phytother Res 1997 11 508-11. 

Feverfew Tanacetum parthenium Altamisa, midsummer daisy, wild chamomile... 

Perhaps the most prominent example with respect to anti-secretive effects of STLs is related to the well-known anti migraine activity of feverfew (Tanacetum parthenium, Asteraceae). The main STL from this plant is parthenolide (PAR), structure 1 in Fig. (15), and it has been shown that PAR is a potent inhibitor of serotonin (5HT)-release from thrombocytes. Although it is not finally clarified to which extent this effect is involved along with the numerous other reported activities of PAR in the clinically proven efficacy of feverfew [71, 72], it should at least contribute to the overall effect. 

Nature Feverfew (Tanacetum parthenium) contains flavonoid glycosides, monoterpenes, and parthenolide, a lactone that forms covalent bonds with thiol groups on proteins. 

Feverfew Tanacetum parthenlum Migraine Antiprostaglandin antiplatelet effects. 

Ernst, E., and M.H. Pittler. 2000. The efficacy and safety of feverfew (Tanacetum parthenium L.) An update of a systematic review. Public Health Nutr. 3(4A) 509-514. 

Loesche, W., W.A. Groenewegen, S. Krause, P. Spangenberg, and S. Heptinstall. 1988. Effects of an extract of feverfew (Tanacetum parthenium) on arachidonic acid metabolism in human blood platelets. Biomed. Biochim. Acta 47(10-11) S241-S243. 

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