Tanacetum parthenium

Heptinstall S, Awang DVS, Dawson BA, Kindack D, Knight DW, May J. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (1.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products. J Pharm Pharmacol 44 391-395, 1992. 

Feverfew (Tanacetum parthenium). Reprinted with permission from Sturdivant and Blakely. (1999). Medicinal Herbs in the Garden, Field, and Marketplace. Friday Flarbor, WA San Juan Naturals. Illustration by Peggy Sue McRae. 

Capasso F. (1986). The effect of an aqueous extract of Tanacetum parthenium L. on arachidonic acid metabolism by rat peritoneal leucocytes. J Pharm Pharmacol. 38(1) 71-72. 

Tanacetum parthenium (L.) Schultz Bip. is the official Latin name for the member of the Compositae family which is more commonly referred to as feverfew [6]. The plant had previously been classified as Chrysanthemum parthenium (L.) Bernh., so the latter name is strictly speaking no longer correct. Other old classifications for feverfew are Leucanthemum parthenium (L.) Gren. Godron or Pyrethrum parthenium (L.) Sm. 

There are at least two varieties of feverfew, the wild variety and a cultivated variety, also known as the golden feverfew or Tanacetum parthenium aureus [7]. The leaves of the golden variety are much yellower than those... 

In 1959-61, a Czech group [8,9] reported the isolation of a new sesquiterpene lactone from Chrysanthemum (Tanacetum) parthenium as part of a study of the sesquiterpene lactones of the Compositae family. They named it parthenolide. The initial structure for parthenolide was later revised [10,11] and the accepted structure for parthenolide today is represented by structure (1). Parthenolide is a germacranolide-type sesquiterpene lactone. The crystal structure for parthenolide has also been reported [12]. Extractions of C. (T.) parthenium grown in Mexico, known locally as santamaria, did not yield parthenolide [13], but a closely related compound was isolated and named santamarine (3). This suggests that regional variations in the chemical constituents may occur. 

English marigold Caienduia officinalis), fennel, yarrow Achillea millefolium), dandelion, angelica, cilantro, feverfew Tanacetum parthenium), tansy Tanacetum vulgare)... 

Ephedra (Ephedra sinica)/Ma Huang Evening Primrose Oil Oenothera biennis) Feverfew Tanacetum parthenium)... 

Long, C. et ah. Bioactive flavonoids of Tanacetum parthenium revisited. Phytochemistry, 64, 567, 2003. 

Williams, C.A. et al., A biologically active lipophilic flavonol from Tanacetum parthenium. Phytochemistry, 38, 267, 1995. 

Feverfew (Tanacetum parthenium) is commonly used for the treatment of migraine headaches, arthritis, and various type of allergies. This herb is thought to exert its pharmacological activity by... 

Tanacetum parthenium Asteraceae Leaves Der Marderosian and Beutler (2002)... 

More than 11,000 Sesquiterpenes have been isolated from natural sources [3]. Feverfew (Tanacetum parthenium (L.) Sch. Bip.,. Compositae) is a common herb utilized for fever, arthritis and migraine. The leaves of feverfew contain large amounts of sesquiterpene lactones. The chloroform extracts of fresh leaves and a commercial leaf product show dose-dependent inhibiting the production of throboxane B2 (TXB2) and leukotriene B4 (LTB4) in rat and human leukocytes. Sesquiterpene lactones isolated from the leaves of feverfew, such as parthenolide and tanaparthin-a-peroxide, demonstrate potent dual inhibitions of COX and LOX pathways with IC50 for COX at 6 17 pg/ml, and for LOX at 12 17 pg/ml, respectively [135],... 

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