Human blood platelets

Compound D is an effective inhibitor of TXA2 biosynthesis in human blood platelets at the micromolar level. 

Champier, J., Claustrat, B., Besancon, R. el al. (1997). Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets. Life Sci 60, 2191-7. 

Rausch, 1., Fefferman, M., Ladisich-Rogers, D., Menard, M. Effect of nicotine on human blood platelet serotonin uptake and efflux. Prog. Neuropsychopharmacol. Biol. Psychiatry. 13 907, 1989. 

A contact dermatitis occurs infrequently. Because feverfew also inhibits human blood platelet aggregation, interactions are possible with antithrombotic medications such as aspirin or warfarin (Groenewegen and Heptinstall 1990). Abrupt discontinuation of feverfew by people taking it chronically for treatment of migraine can produce rebound withdrawal symptoms. These consist of migraines, anxiety, poor sleep patterns, and stiffness of the muscles and joints. 

Miao, W.M., Vasile, E., Lane, W.S., and Lawler, J., 2001, CD36 associated with CD9 and integrins on human blood platelets. Blood 97 1689-1696. 

Oda, A., Daley, J. F., Cabral, C., Kang, J., Smith, M., and Salzman, E. W. (1992) Heterogeneity in filamentous actin content among individual human blood platelets. Blood 79, 920-927. 

F. Ushikubi, M. Nakajima, M. Hirata, M. Okuma, M. Fujiwara, S. Narumiya, Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets, J. Biol. Chem. 264(1989) 16496. 

Greenberg, B.D., Tolliver, T.J., Huang, S.J., Li, Q., Bengel, D., and Murphy, D.L. (1999) Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88 83-87. 

Srivastava, . C. and N. Malhotra. 1991. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot. Essent. Fatty Acid 42 73-81. 

A quantitative indication of the importance of the cAMP system within cells can be derived from measurement of the kinetics of the incorporation of lsO from water into the a-phospho groups of AMP, ADP, and ATP. This incorporation will result from hydrolysis of cAMP by the phosphodiesterases that allow relaxation to a low cAMP level (Eq. 11-8). It is thought that in human blood platelets this represents the major pathway of this labeling (Eq. 11-9), which occurs at a rate of about 1.1 prnol of lsO kg s . 

Neiva TJC, Fries DM, Monteiro HP, et al. 1997. Aluminum induces lipid peroxidation and aggregation of human blood platelets. Braz J Med Biol Res 30 599-604. 

M29. Myllyla, G., Aggregation of human blood platelets by immune complexes in the sedimentation pattern test. Scand. J. Haematol. Suppl. 19, 1-50 (1973). 

Srivastava, K.C. (1 989) Extracts from two frequently consumed spices - cumin (Cuminum cyminum) and turmeric (Curcuma longa) - inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets. Prostaglandins, Leukotrienes and Essential Fatty Acids 37(1), 57-64. 

A group of 3-oxoisothiazolopyrimidines (164) have been patented for their ability to inhibit human blood platelet aggregation (77GEP2718707). 3,6-Dialkylisothiazolo[3,4-d]pyrimidin-4(5H)-ones (165) show useful herbicidal activity (73GEP2249099). 

This review will deal primarily with this contractile protein from human blood platelets, which we have named thrombosthenin in view of its origin and function. A brief review on blood platelets in general and their role in hemostatis will be included. The role of thrombosthenin for platelet function will be discussed and its properties compared with those of other contractile proteins. 

In 1959 Bettex-Galland and Liischer succeeded in extracting from human blood platelets such a (iontractile protein, which was subsecpiently named thrombosthenin. Its solubility properties, as well as its dependence for activity on the presence of ATP and metal ions, soon led to its classification as a member of the actomyosin group. Work on thrombosthenin has since continued, both with respect to its properties as a complex protein with enzymatic activity and to its biological significance. 

Mehrishi, J. N., The Human Blood Platelets as a Molecular Mosaic—Its... 

Rao GHR White JG. Influence of phospholipase A2 on human blood platelet alpha adrenergic receptor ftmctioiL Triiomb. Res. 1989 53 427-34... 

Nieuwenhuis HK, Akkermann JWN, Houdijk WPM, Sixma JJ Human blood platelets showing no respcaise to collagen fail to express surface glycoprotein la. Nature 318 470-472,1985... 

Wicki AN, Clemetson KJ. The glycoprotein Ib complex of human blood platelets. Eur J Biochem 1987 163 43-50. 

Sohm NO, Stomoiken H. Influence of fibrinogen on the aggregation of washed human blood platelets induced by adenosine diphosphate, thrombin, collagen, and adrenalin. ScsaidXLdb Invest 1965 17 170-182. 

Peo-schke El, Zucker MB. Fibrinogen receptor exposure and aggregation of human blood platelets produced by ADP and dulling. Blood 1981 57 663-339. 

LEBOWIIZ EA, Cooker Contradile properties of actomyosin from human blood platelets. JBiol Chem 253 5443-.5447,1978. 

Mills DCB. changes in the adenylate energy charge in human blood platelets induced by adenosine diphos diate. Nature Ne>v Biol 243 220,1973. 

More N, Teru-uchi T, Tominaga T, Kumagi N, Kozaki S, Ushkubi F, Narumiya S. a Rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by botulinum C3 ADP-ribosyltransferase on platdet aggr atioa JBiol Chem 267 20921-20926,1992. 

Nemoto Y, Namba T, Teru-uchi T, Ushkubi F. More N, Narumiya S. a rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein. JBiol Chem 267 20916-20920,199Z... 

PEERSCHKE EIB, GHEBREHIWBT B. Human blood platelets possess ecific binding sites for Clq. JImmunol 138 1537-1541,1986. 

SALZMA EW. Interrelation of prostaglandin endoperoxide PGGj and cyclic 3 ,5 adenosine monophosphate in human blood platelets. Biochim Biophys Acta 499 48-60,1977. 

Marcus AJ, Utlman HL, and Safier LB. (1969). Lipid c nposition of subcellular particles of human blood platelets. J. Lipid Res. 10,108-114. 

Croset M, Bayon Y, and Lagarde M. (1992). Incorporation and turnover cf eicosapoitaaioic and docosahexaenoic acids in human blood platelets in vitro. Biocheia J. 281,309-316. 

Huang PY, HeUums JD. Aggregation and disaggregation kinetics of human blood platelet Part H. Shear-induced platelet aggrcgaticai. BiophysJ 1993 65 344-353. 

Extracts of the leaves of T. parthenium inhibit the secretion of granules from human blood platelets and polymorphonuclear leucocytes. The antiplatelet activities of feverfew are due to phospholipase inhibition which prevents the release of arachidonic acid, that is the precursor both of prostoglandins and the leukotriens. The diverse pharmacological activities of feverfew is based on this mode of action [188-196]. 

Inhibition of human blood platelet function and the possible relevance of this effect to migraine prophylaxis by feverfew was also discussed by Hewlett et al. [228]. 

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