Sesquiterpene lactones isolation

Foglio MA, Dias PC, Antonio MA, Possenti A, Rodrigues RA, da Silva EF, Rehder VL, de Carvalho JE. (2002) Antiulcerogenic activity of some sesquiterpene lactones isolated from Artemisia annua. Planta Med 68 515-518. 

Figure 2. Sesquiterpene lactones isolated from the Ambrosia aumanensis-psilostaahya complex.

Stiles, L. H., Leather, G. R., and Chen, P. K. 1994. Effects of two sesquiterpene lactones isolated from Artemisia annua on physiology of Lemna minor. J. Chem. Ecol. 20, 969-978... 

More than 11,000 Sesquiterpenes have been isolated from natural sources [3]. Feverfew (Tanacetum parthenium (L.) Sch. Bip.,. Compositae) is a common herb utilized for fever, arthritis and migraine. The leaves of feverfew contain large amounts of sesquiterpene lactones. The chloroform extracts of fresh leaves and a commercial leaf product show dose-dependent inhibiting the production of throboxane B2 (TXB2) and leukotriene B4 (LTB4) in rat and human leukocytes. Sesquiterpene lactones isolated from the leaves of feverfew, such as parthenolide and tanaparthin-a-peroxide, demonstrate potent dual inhibitions of COX and LOX pathways with IC50 for COX at 6 17 pg/ml, and for LOX at 12 17 pg/ml, respectively [135],... 

Table 6. The Minimal Inhibitory Concentrations (lig.mT ) of Sesquiterpene Lactones Isolated from T. densum ssp. sivasicum Against a Range of Microorganisms...

Sesquiterpene lactones isolated from T. densum ssp. sivasicum were evaluated for cytotoxic activity against human epidermoid (KB) cells. Tavulin, spiciformin and dentatin A were found to be active with the IC50 values of 3.2, 2.9 and 2.4 pgml, respectively, whereas tanachin was inactive [36]. 

Table 8. Cytotoxic Activity (in ICgo values pM + sd n=3) of the Sesquiterpene Lactones Isolated from T. praeteritum ssp. praeteritum Against the Human Cell Lung Carcinoma Cell Line (GLC4) and the Human Colorectal Cancer Cell Line (COLO 320)...

A short-step synthesis of l-oxoeudesma-2,4-dien-l l)3i/-12,6a-olide (65), a sesquiterpene lactone isolated from Artemisia herba-alba, has been devised by Kawamata and coworkers [19]. The synthesis (Scheme 9) involved the reduction of santonin to compounds 36a and 36b and their oxidation with pyridinium chlorochromate (PCC) in CH2CI2 to give 9% of the rearranged product 65 and 30% of santonin. This procedure... 

Spanish researchers [24] have undertaken the synthesis of 11 -angeloxy-a-santonin (104) in an attempt to clarify the stereostructures of decipienin A and other sesquiterpene lactones isolated from Umbelliferae species, i.e. structures of type 91(a) (5j8//, 6aH, laH, 10a, llj8-methyleudesman-6,12-olide) versus structures of type 91(b) 5aH, 6fiH, laH, 10j8, 1 la-methyleudesman-6,12-olide). Structures of type 91(b) were, as a result of this synthesis, shown not to be present in such compounds. 

Fig. 6.7 Sesquiterpene lactones isolated from the fruits of Laums nobilis L...

Sesquiterpene lactones isolated from bai-zhu atractylodes inhibited contractions induced by acetylcholine and oxytocin in isolated rat uteri (Zhang et al. 2000). 

Sesquiterpene lactone isolated from the Compositae plant Saussurea lappa. Costunolide is present in the plant together with dehydrocostus lactone... 

CoeUio F, Diaz G. Studies on the synthesis of ( )-pathylactone A, a nor-sesquiterpene lactone isolated from marine sources. Tetrahedron 2002 58(9) 1647-1656. 

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