Tanacetum Parthenium Feverfew

FIGURE 25.2 Sites of action of aspirin, colchicine, and parthenolide. 

Parthenolide may have a similar mechanism of action as seen following administration of sumatriptan, which is an effective analgesic and antimigraine drug. Sumatriptan has a selective agonist for serotonin receptor subtype, causing vasoconstriction of cranial arteries. 

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Tanacetum parthenium (feverfew, bachelor s buttons, motherherb) has been used in the prevention of migraine, with some benefit (43), and for rheumatoid arthritis, without (44). 

Silybum marianum (milk thistle) Tanacetum parthenium (feverfew) Tussilago farfara (coltsfoot)... 

Tanacetum parthenium (feverfew) Asteraceae (aster) Chamomile Matricaria recutita... 

Pfaffenrath V, Diener HC, Fischeer M, Friede M, Henneicke-von Zepelin HH. The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxix— a double-blind, multicentre, randomized placebo-controlled dose-response study. Cephalalgia 2002 22(7) 523-532. 

Tanacetum parthenium Feverfew Altamisa, midsummer daisy, wild chamomile... 

Heptinstall S, Awang DVS, Dawson BA, Kindack D, Knight DW, May J. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (1.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products. J Pharm Pharmacol 44 391-395, 1992. 

Feverfew (Tanacetum parthenium). Reprinted with permission from Sturdivant and Blakely. (1999). Medicinal Herbs in the Garden, Field, and Marketplace. Friday Flarbor, WA San Juan Naturals. Illustration by Peggy Sue McRae. 

Tanacetum parthenium (L.) Schultz Bip. is the official Latin name for the member of the Compositae family which is more commonly referred to as feverfew [6]. The plant had previously been classified as Chrysanthemum parthenium (L.) Bernh., so the latter name is strictly speaking no longer correct. Other old classifications for feverfew are Leucanthemum parthenium (L.) Gren. Godron or Pyrethrum parthenium (L.) Sm. 

There are at least two varieties of feverfew, the wild variety and a cultivated variety, also known as the golden feverfew or Tanacetum parthenium aureus [7]. The leaves of the golden variety are much yellower than those... 

English marigold Caienduia officinalis), fennel, yarrow Achillea millefolium), dandelion, angelica, cilantro, feverfew Tanacetum parthenium), tansy Tanacetum vulgare)... 

Ephedra (Ephedra sinica)/Ma Huang Evening Primrose Oil Oenothera biennis) Feverfew Tanacetum parthenium)... 

Feverfew (Tanacetum parthenium) is commonly used for the treatment of migraine headaches, arthritis, and various type of allergies. This herb is thought to exert its pharmacological activity by... 

More than 11,000 Sesquiterpenes have been isolated from natural sources [3]. Feverfew (Tanacetum parthenium (L.) Sch. Bip.,. Compositae) is a common herb utilized for fever, arthritis and migraine. The leaves of feverfew contain large amounts of sesquiterpene lactones. The chloroform extracts of fresh leaves and a commercial leaf product show dose-dependent inhibiting the production of throboxane B2 (TXB2) and leukotriene B4 (LTB4) in rat and human leukocytes. Sesquiterpene lactones isolated from the leaves of feverfew, such as parthenolide and tanaparthin-a-peroxide, demonstrate potent dual inhibitions of COX and LOX pathways with IC50 for COX at 6 17 pg/ml, and for LOX at 12 17 pg/ml, respectively [135],... 

HAUSEN, B.M., Occupational contact allergy to feverfew Tanacetum parthenium (L.) Schultz-Bip. Asteraceae., Derm. Beruf. Umwelt., 1981,29,18-21. 

Chmopodia rubrum (Chenopodicaceae), Tanacetum parthenium (Chrysanthemum) (feverfew) (Asteraceae) edible plant seeds animal pineal gland metabolized to 5-Methoxytryptamine... 

As Tanacetum parthenium is rich in allergenic sesquiterpene lactones, such as parthenolide, it is not surprising that contact dermatitis has been observed (SEDA-11, 426). The most common adverse effect of oral feverfew is mouth ulceration. A more widespread inflammation of the oral mucosa and tongue, swelhng of the lips, and loss of taste have also been reported. 

Angei s trumpet Datura suaveolens Feverfew Tanacetum parthenium... 

Tanacetum parthenium Chrysanthemum parthenium) is known feverfew. "Feverfew" comes from the Latin fetrifugia meaning driver out of fevers and it has been used for centuries as an antipyretic. Traditionally, the leaves or infussions of the herb have long been used as a febrifuge and to relieve menstrual and rheumatic pain and migraine [11]. Nowadays standardized feverfew capsules containing the leaf extract are available in the market. 

Feverfew. Tanacetum parthenium (L.) Schultz Bip. is an herb that was used in antiquity to reduce fever and pain. The literature is replete with anecdotal evidence of the usefulness uf the herb, and recent clinical studies have added more support. Feverfew is a member of the aster/dai.sy family. The plant tissues have a pungent smell and very bitter taste. The medicinal principle of feverfew is concentrated in hairy trichomes on the chiysanthemum-like leaves.The plant displays clusters uf daisy-like flowers with yellow centers and radiating white florets. Recent uses uf feverfew are for migraine and arthritis, although the indication for arthritis is disputable. The anecdotal evidence that an herb could successfully treat a condition such as migraine headache naturally begged for some seientifle proof. 

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