Fetal Alcohol Syndrome/FAS

Fetal alcohol syndrome (FAS) is a pattern of birth defects caused by maternal consumption of ethanol during pregnancy. It is recognized by growth deficiency, a characteristic set of craniofacial features and neurodevelopmental abnormalities leading to cognitive and behavioral deficits [85]. FAS is considered to be the most common non-hereditary cause of mental retardation. 

Toxicologists nowadays take a broad view of developmental toxicity they consider not only structural but also functional abnormalities to qualify as adverse, as long as they were produced as a result of exposures incurred in utero. Thus, for example, the developmental effects of chronic alcohol abuse by pregnant women, known as fetal alcohol syndrome (FAS), are characterized not only by the presence of certain craniofacial abnormalities, but also by a variety of disabilities such as shortened attention span, speech disorders, and restlessness. Although fully expressed physical deformities included in FAS are associated with heavy drinking, debate continues on the level of alcohol consumption, if any, that is without these more subtle effects on behavior. 

Absorption readily absorbed by intestine, food will delay absorption Sensitive individuals fetus (fetal alcohol syndrome - FAS) Toxicity/symptoms developing nervous system very sensitive to low levels of exposure children - lowered IQ, learning and behavioral problems adults — memory loss, inebriation, liver disease, cancer... 

Nowhere are the effects of the permeability of the placental membrane more graphic than in the incidence of fetal alcohol syndrome (FAS) in the children of alcoholic mothers. FAS produces distinctive anatomical features and mental retardation. Ethanol is called a teratogen because it causes genetic malfunction. Recall that thalidomide was a teratogen. 

More than 60,000 infants suffer from fetal alcohol syndrome (FAS), a condition that is largely irreversible and whose effects include serious developmental and learning problems. 

Fetal Alcohol Syndrome. Fetal alcohol syndrome (FAS) is a pattern of mental and physical defects that develops in some offspring when exposed to alcohol in utero. The first trimester is the most susceptible period. Some babies with alcohol-related birth defects, such as lower birth weight and body size and neurological impairments, do not have all of the classic FAS symptoms. These outcomes are often referred to as fetal alcohol effects (FAE). Currently there is not total agreement among medical scientists concerning the precise differences between FAE and FAS. In addition to growth retardation, the most common outcomes of fetal alcohol syndrome include psychomotor dysfunction and craniofacial anomalies. 

Since the discovery of the fetal alcohol syndrome (FAS), extensive research has been carried out on the teratogenic effects of alcohol The consequences of early exposure to this substance can serve to illustrate the multiplicity of effects that a chemical can cause. Chronic exposure of the fetus to high levels of alcohol has been found to result in many cases in a large spectrum... 

Ferritin, 739, 741,742, 756, 760 Fetal alcohol syndrome (FAS), 250, 251 FFAs, self Free falty acids Fiber, see Dietary fiber Fibrinogen, 49,530 Fibrous plaque, 360 Filamentous phage, DN A sequencing, 954-955 Fish oils, 643... 

Table 9.6 lists the major effects of chronic heavy drinking on body systems. As you can. see, alcohol can be highly toxic to the human body and cause extensive damage to it in a variety of ways. Two prominent body systems that alcohol harms are the brain and the liver. We will look at alcohol s chronic effects on these systems in more detail. Alcohol s chronic effects also extend to human reproductive fimetioning, which has to do with alcohol s altering the fimetioning of the hypothalamic-pituitary-gonadal endocrine axis and with fetal alcohol syndrome (FAS). 

A mother s drinking during pregnancy may result in fetal alcohol syndrome (FAS) in the newborn child. 

Fetal alcohol syndrome (FAS) is a set of birth defects caused by maternal consumption of alcohol during pregnancy. FAS is considered the most common... 

The effect of alcohol consumption leading to the development of fetal alcohol syndrome (FAS) has been investigated by the proteomic analysis of amniotic fluid of mice. In mice with FAS, the level of alpha fetoprotein is reduced markedly, which may be used as a biomarker of FAS. 

Datta, S., D. Turner, R. Singh, L.B. Ruest, W.M. Pierce, and T.B. Knudson. 2008. Fetal alcohol syndrome(FAS) in C57BL/6mice detected through proteomics screening of the amniotic fluid. Clin. Molec. Teratol., 82, 177-186. 

The use of alcoholic beverages by a pregnant woman can cause fetal alcohol syndrome (FAS). A syndrome is a set of symptoms that occur together and are characteristic of a particular disease. In this case, physicians have observed that infants born to women with chronic alcoholism showed a reproducible set of abnormalities including mental retardation, poor growth before and after birth, and facial malformations. 

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