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Spliced leader

Trans splicing. Every mRNA in trypanosomes has, at its 5 end, a short 35-nucleotide sequence that is not encoded in the transcribed gene. It was found that for each mRNA molecule two transcripts are formed and are spliced together, always with the 5 piece from a short SL (spliced leader) gene being joined to each of the others.639 This trans splicing has since been observed in many plants, animals, and protists.640... [Pg.1647]

Spliced leader RNA trans-splicing is a form of RNA editing in which a short RNA exon (the... [Pg.48]

Table 2.5. Platyhelminth spliced leader RNAs/genes. Table 2.5. Platyhelminth spliced leader RNAs/genes.
Spliced leader (length) Enolase frans-splicing Reference... [Pg.49]

Brehm, K., Hubert, K., Sciutto, E., Garate, T. and Frosch, M. (2002) Characterization of a spliced leader gene and of trans-spliced mRNAs from Taenia solium. Molecular and Biochemical Parasitology 122, 1 05-11 0. [Pg.69]

Davis, R.E. (1997) Surprising diversity and distribution of spliced leader RNAs in flatworms. Molecular and Biochemical Parasitology 87, 29—48. [Pg.70]

Davis, R.E., Singh, H., Botka, C., Hardwick, C., Ashraf el Meanawy, M. and Villanueva, J. (1994) RNA transsplicing in Fasciola hepatica. Identification of a spliced leader (si) RNA and si sequences on mRNAs. Journal of Biological Chemistry 269, 20026-20030. [Pg.70]

Rajkovic, A., Davis, R.E., Simonsen, J.N. and Rottman, F.M. (1990) A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni. Proceedings of the National Academy of Sciences USA 87, 8879-8883. [Pg.77]

Stratford, R. and Shields, R. (1 994) A frans-spliced leader RNA sequence in plant parasitic nematodes. Molecular and Biochemical Parasitology 67, 147-1 55. [Pg.78]

Brehm, K., Wolf, M., Beland, H., Kroner, A. and Frosch, M. (2003) Analysis of differential gene expression in Echinococcus multilocularis larval stages by means of spliced leader differential display. International Journal for Parasitology 33,1 145-1 1 59. [Pg.167]

Mechanism of Trans-Splicing the Spliced-Leader RNAs... [Pg.9]

In addition to providing a discrete 5 end for mRNAs, trans-splicing also provides each mRNA with the cap structure derived from the SL RNA. Although it remains to be established whether translation in trypanosomes or nematodes is cap dependent, it seems likely that the cap, as it is in other eukaryotes, will be essential for mRNA recognition by ribosomes. It remains to be determined whether spliced leader or cap addition is necessary for transport of mRNAs from the nucleus or influences mRNA stability. [Pg.13]

Krause, M. and Hirsh, D. (1987) A rrans-spliced leader sequence on actin mRNA in C. elegans. Cell 49 753-761. [Pg.16]

Maroney, P. A., Hannon, G. J., Shambaugh, J. D. and Nilsen, T. W. (1991) Intramolecular base pairing between the nematode spliced leader and its 5 splice site is not essential for trans-splicing in vitro. EMBO J. 10 3869-3875. [Pg.17]

Bektesh, S. L., van Doren, K. V. and Hirsh, D. (1988) Presence of the Caenorhabditis elegans spliced leader on different mRNAs and in different genera of nematodes. Genes Dev. 2 1277-1283. [Pg.17]

Perry K, A bian N. mRNA processing in the Ttypanosomatidae. Experientia 1991 47 118-128. Das A, Zhang Q, Palenchar JB et al. Trypanosomal TBP functions with the multisubunit transcription factor tSNAP to direct spliced-leader RNA gene expression. Mol Cell Biol 2005 ... [Pg.139]

Schitnanski B, Nguyen TN, Gunzl A. Characterization of a multisubunit transcription ctor complex essential for spliced-leader RNA gene transcription in Trypanosoma brucei. Mol Cell Biol 2005 25(16) 7303-7313. [Pg.139]

Schimanski B, Brandenbu J. Nguyen TN et al. A TFIIB-like protein is indispensable for spliced leader RNA gene transcription in Trypanosoma brucei. NucI Acids Res 2006 34(6) 1676-1684. Anantharaman V, Aravind L, Koonin EV. Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins. Curr Opin Chem Biol 2003 7(l) 12-20. Clayton CE. Life without ttanscriptional control From fly to man and back ain. EMBO J 2002 21(8) 1881-1888. [Pg.139]

Bruzik, J.P. Maniatis, T. (1992) Nature (London) 360, 692-695. Spliced leader RNAs from lower eukaryotes are frans-spliced in mammalian cells. [Pg.102]

Kuo, R.C., Zhang, H., Zhuang, Y., Harmick, L., Lin, S., 2013. Transcriptomic study reveals widespread spliced leader frans-spUcing, short 5 -UTRs and potential complex carbon fixation mechanisms in the euglenoid Alga Eutreptiella sp. PLoS One 8 (4), e60826. [Pg.356]

See other pages where Spliced leader is mentioned: [Pg.186]    [Pg.49]    [Pg.49]    [Pg.50]    [Pg.145]    [Pg.156]    [Pg.215]    [Pg.215]    [Pg.236]    [Pg.237]    [Pg.318]    [Pg.3]    [Pg.7]    [Pg.8]    [Pg.9]    [Pg.16]    [Pg.16]    [Pg.17]    [Pg.258]    [Pg.470]   
See also in sourсe #XX -- [ Pg.45 , Pg.48 , Pg.49 , Pg.49 , Pg.56 ]



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