Alpha-ketoglutarate dehydrogenase

Diaz, F. and Komuniecki, R.W. (1996) Characterization of the alpha-ketoglutarate dehydrogenase complex from Fasciola hepatica potential implications for the role of calcium in the regulation of helminth mitochondrial metabolism. Molecular and Biochemical Parasitology 81,243—246. [Pg.288]

Krebs cycle Inhibition of aconitase by superoxide and fluoroacetate, of succinate dehydrogenase by methamphetamine and mal-onate, of alpha-ketoglutarate dehydrogenase by salicylic add... [Pg.334]

Thiamine (vitamin Bi) is phosphorylated by ATP to thiamine pyrophosphate. This is a coenzyme for, among others, alpha-ketoglutarate dehydrogenase, transketolase and pyruvate dehydrogenase. Thiamine pyrophosphate is involved in fatty acid... [Pg.473]

Pekovich SR, Martin PR and Singleton CK (1998) Thiamine deficiency decreases steady-state transketolase and pyruvate dehydrogenase but not alpha-ketoglutarate dehydrogenase mRNA levels in three human cell types. Journal of Nutrition 128, 683-7. [Pg.446]

Mizuno Y, Matuda S, Yoshino H, Mori H, Hattori N, Ikebe S (1994) An immunohistochemi-cal study on alpha-ketoglutarate dehydrogenase complex in Parkinson s disease. Ann Neurol 35(2) 204-210... [Pg.123]

A. Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. J. Pediatr. 1992 121 255-258. [Pg.1122]

Bonnefont JP, Chretien D, Rustin P, Robinson B, Vassault A, Aupetit J, Charpentier C, Rabier D, Saudubray JM, Munnich A. Alpha-ketoglutarate dehydrogenase deficiency presenting as congenital lactic acidosis. J. Pediatr. 1992 121 255-258. [Pg.1123]

R. G. McCartney, J.E. Rice, S.J. Sanderson, V. Bunik, H. Lindsay, and J.G. Lindsay. 1998. Suhunit interactions in the mammalian alpha-ketoglutarate dehydrogenase complex Evidence for direct association of the alpha-ketoglutarate dehydrogenase and dihydrolipoamide dehydrogenase components J. Biol. Chem. 273 24158-24164. (PubMed)... [Pg.732]

Active form of thiamine, that is thiamine pyrophosphate (TPP) is required for the key reactions catalyzed by Pyruvate dehydrogenase complex and alpha-ketoglutarate dehydrogenase complex (TCA cycle). [Pg.243]

D.T. Lucas and L.I. Szweda, Declines in mitochondrial respiration during cardiac reperfusion age-dependent inactivation of alpha-ketoglutarate dehydrogenase, Proc. Natl. Acad. Sci. USA. 96(12), 6689-6693 (1999). [Pg.66]

Nulton-Persson AC, Starke DW, Mieyal JJ, Szweda Ll (2003) Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status. Biochemistry 42 4235-4242... [Pg.107]

Blum, J. J., and Ginsburg, H. (1984). Absence of alpha-ketoglutarate dehydrogenase activity and presence of CCh-fixing activity in Plasmodium falciparum grown in vitro in human erythrocytes. ]. Protozool. 31,167-169. [Pg.331]

Decarboxylation and oxidation of alpha-ketoglutarate is carried out by a large multienzyme complex. Both in the overall reaction it catalyzes and in the cofactors used to carry them out—the alpha-ketoglutarate/dehydrogenase complex (alpha-KGDC)—it is similar to the reaction scheme of the pyruvate dehydrogenase (PDC) complex (see Figure 10-6). [Pg.143]

Like the pyruvate dehydrogenase complex, the alpha-ketoglutarate dehydrogenase complex has three enzymatic activities, and the same cofactors. As might be expected, the primary sequences of the proteins are highly similar, indicating that they diverged from a common set of ancestral proteins. [Pg.144]

Ishikawa, E., Oliver, R. Reed, L. (1966) Proc. Natl. Acad. Sci. 56, 534-541. Alpha-Keto acid dehydrogenase complexes, V. Macromolecular organization of pyruvate and alpha-ketoglutarate dehydrogenase complexes isolated from beef kidney mitochondria. [Pg.154]

Cafingasan, N. Y, et al., 1994a. Distribution of the alpha-ketoglutarate dehydrogenase complex in rat brain. J Comp Neurol. 346, 461 79. [Pg.257]

Huang, H. M., et al., 2003. Inhibition of alpha-ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase-3 activation, and necrotic cell death. J Neurosci Res. 74, 309-317. [Pg.258]

Jeitner, T. M., et al., 2005. Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. J Neurochem. 92, 302-310. [Pg.258]

Mastrogiacomo, R, Kish, S. J., 1994. Cerebellar alpha-ketoglutarate dehydrogenase activity is reduced in spinocerebellar ataxia type 1. Ann Neurol. 35, 624-626. [Pg.259]

Shi, Q., et al., 2007. Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may contribute to regional selective vulnerability. Neurochem Int. 50, 921-931. [Pg.259]

Starkov, A. A., et al., 2004. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci. 24, 7779-2788. [Pg.259]

Chinopoulos, C. (2013) Which way does the citric acid cycle turn during hypoxia The critical role of alpha-ketoglutarate dehydrogenase complex. J. Neurosci. Res. 91 1030-1043. [Pg.13]

Holz M, Otto C, Kretzschmar A, Yovkova V, Aurich A, Poetter M, et al. Overexpression of alpha-ketoglutarate dehydrogenase in Yarrowia lipolytica and its effect on production of organic acids. Appl... [Pg.435]

Mastrogiacoma, F., Lindsay, J.G., Bettendorff, L., Rice, J., and Kish, S.J., 1996. Brain protein and alpha-ketoglutarate dehydrogenase complex activity in Alzheimer s disease. Annals of Neurology. 39 592-598. [Pg.583]

Haworth, J.C., Perry, T.L., Blass, J.P., Hansen, S. and Urquhart, N. (1976), Lactic acidosis in 3 sibs due to defects in both pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase complexes. Pediatrics, 58,564. [Pg.400]

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