Cellular slime molds

Newel PC, Aggregation and cell surface receptors in cellular slime molds. In Cuatrecasas P, Greaves ME (eds.). Receptors and Recognition, pp. 1—58, 1977. 

Animal cells also produce lectins.24 105 185 193 The amebas of the cellular slime mold Dictyostelium synthesize a classical lectin called discoidin I that binds GalNAc or Gal. It is absent from cells until they... 

Some species of cellular slime molds use other chemical attractants (acrasins). For example, D. minutum secretes an analog of folic acid1 and cells of Polysphondylium violaceum are attracted by the ethyl ester of N-propionyl-y-L-glutamyl-L-ornithine-8-lactam.s... 

Early studies revealed that the 3, 5 -cyclic phosphate diesterase is present in all mammalian tissues (38, 33, 36), being most active in cerebral cortex (36, 37). It has also been identified in extracts of liver fluke (Fasciola hepatica), the common earthworm (Lumbricus terrestris), and fly larvae (36) and it has been studied in marine organisms (38), the cellular slime mold Dictyostelium discovdeum (39, AO), and in E. coli (Al). The enzyme has been partially purified from beef heart (30), dog heart, (A8) and bovine brain (37, A3). No highly purified preparations have yet been obtained and most studies have been performed with relatively crude preparations. 

The cellular slime mold Dictyostelium purpureum K1001 contains AB0022A (2255), a novel antibacterial dibenzofuran, the structure of which was confirmed by total synthesis (2038). The lichen Lecanora cinereocarnea has yielded several new dibenzofurans, including three chlorinated analogues (2256-2258) (2039), and Lecanora iseana contains 2259 and 2260 (2040). The first naturally occurring polybrominated dibenzofuran, corallinafuran (2261), is present in a crustose coralline red alga that also contains corallinaether (1913) cited earlier (1769). 

Sawada T, Aono M, Asakawa S, Ito A, Awano K (2000) Structure Determination and Total Synthesis of a Novel Antibacterial Substance, AB0022A, Produced by a Cellular Slime Mold. J Antibiotics 53 959... 

Both actin and myosin are present in nonmuscle cells. Actin is a highly conserved protein in organisms ranging from cellular slime molds to humans, whereas myosin is less well conserved. Within nonmuscle cells these two proteins are involved in such processes as cell movement, the transport of membrane-bound subcellular organelles around the cell on actin tracks, and cell division (see Topic A2). 

E. F. Keller, The force of the pacemaker concept in theories of aggregation in cellular slime mold," Perspectives in Biology and Medicine 26 (4) (1983) 515-521. 

The enzyme activity was from the cellular slime mold Dictyostelium mi-nutum. 

Dictyostelium discoideum is a cellular slime mold, an amoeba. It is a preferred object for the study of cell locomotion, chemotaxis and differentiation. 

The most important compounds from this class are undoubtedly 3,6-anhydrofuranoses. Fura-nodictine A and B (produced by cellular slime mold Dictyostelium discoideum) showing neuronal differentiation activity [54] are good examples. These interesting derivatives may be conveniently obtained from the open-chain sugars. For example, synthesis of furanodictine A was realized from compound 85 obtained from D-arabinose in a few well-defined steps as shown inO Fig. 19 [55]. 

The structural elucidation of the secondary metabolites of Dictyosteiiium cellular slime molds was achieved by Y. Oshima et al. The total synthesis of a novel compound, dictyopyrone A, which possesses a unique a-pyrone moiety with a side-chain at the C3 position, was successfully carried out using the maionic ester synthesis. Meldrum s acid was acylated and the product was subjected to transesterification with an optically active did. Specific rotation of the final product was identical with that of the natural product, so the absolute configuration was established as (S). 

Barchilon, M. L.A. Segel. 1988. Adaptation, oscillations and relay in a model for cAMP secretion in cellular slime molds. J. Theor. Biol 133 437-46. 

Bonner, J.T. 1%7. The Cellular Slime Molds. Princeton Univ. Press, Princeton, NJ. 

Cohen, M.H. A. Robertson. 1971. Wave propagation in the early stages of aggregation of cellular slime molds. J. Theor. Biol. 31 101-18. 

Schaap, P. M. Wang. 1984. The possible involvement of oscillatory cAMP signaling in multi-cellular morphogenesis of the cellular slime molds. Dev. Biol. 105 470-8. 

The biosynthesis of trehalose has also been studied during various stages of development, especially in the cellular slime-mold Dictyostelium... 

Novel bioactive 0-heterocycles isolated from unexploited organisms, cellular slime molds 07YZ1431. 

Chemotaxis, i.e., the oriented movement of freely motile and free living amoebae, and in particular of the cellular slime molds, has been analyzed in great detail (see Chapter 5). Like other organisms, Dic-tyostelium and other Acrasiales react preferentially to compounds which signal the presence of prey bacteria, or of other cells of their species. 

Rogers MJ, Ji XH, Russell RGG, Blackburn GM, Williamson MP, Bayless AV, Ebetino FH, Watts DJ (1994) Incorporation of bisphosphonates into adenine-nucleotides by amebas of the cellular slime-mold dictyostelium-discoideum. Biochem J 303 303-311... 

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