Pharmaceuticals, extrusion

Chemicals Manufacturing Distribution Plastics Sheet Extrusion Pharmaceuticals Paints Coatings... 

Leister, D., Geilen, T., and Geissler, T. Twin-screw extruders for pharmaceutical hot-melt extrusion Technology, techniques and practices. In Douroumis, D. (ed.), Hot-Melt Extrusion Pharmaceutical Applications, 1st edn. Wiley, Chichester, U.K., 2012, pp. 23-42. 

Ghebremeskel A, Vemavarapu C et al (2007) Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API selection of polymer-surfactant combinations using solubility parameters and testing the processability. Int J Pharm 328(2) 119-129 Gogos C, Liu H (2012) Laminar dispersive and distributive mixing with dissolution and applications to hot-melt extrusion. In Douroumis D (ed) Hot-melt extrusion pharmaceutical applications. Wiley, New York, pp 261-284... 

Tableting, pressing, mol ding, and extrusion operations are commonly used to produce agglomerates of well-defined shape, dimensions, and uniformity in which the properties of each item are important and output is measured in pieces per hour (see Ceramics, ceramics processing Pharmaceuticals Metallurgy, powderp tallurgy Plastics processing).

Pharmaceutical Extrusion Technology, edited by Isaac Ghebre-Sellas-sie and Charles Martin... 

Poly(phenylenepyrazoles), 5, 300 Polypyrazoles, 5, 300 N-substituted, 5, 300 Polypyrazolines, 5, 300 Poly(pyrazol-l-yl) borates as ligands, S, 225, 235 Polypyrroles applications, 4, 376 Polypyrrole tetrafluoroborate conductors, 1, 355 Polysaccharides as pharmaceuticals, 1, 152 Poly-2,5-selenienylenes applications, 4, 971 Polysilacyclopentanes, 1, 609 Polysufides macrocyclic sulfur extrusion, 7, 777... 

Substitute for Conventional Vulcanized Rubbers, For this application, the products are processed by techniques and equipment developed for conventional thermoplastics, ie, injection molding, extrusion, etc. The S—B—S and S—EB—S polymers are preferred (small amounts of S—EP—S are also used). To obtain a satisfactory balance of properties, they must be compounded with oils, fillers, or other polymers compounding reduces costs. Compounding ingredients and their effects on properties are given in Table 8. Oils with high aromatic content should be avoided because they plasticize the polystyrene domains. Polystyrene is often used as an ingredient in S—B—S-based compounds it makes the products harder and improves their processibility. In S—EB—S-based compounds, crystalline polyolefins such as polypropylene and polyethylene are preferred. Some work has been reported on blends of liquid polysiloxanes with S—EB—S block copolymers. The products are primarily intended for medical and pharmaceutical-type applications and hardnesses as low as 5 on the Shore A scale have been reported (53). 

The twin-screw extrusion (TSE) technology is utilized extensively in the plastics and food industries to complement continuous manufacturing of products. Ghebre-Sellassie et al. [37] and Keleb et al. [36] have cited the application of this technology in the continuous production of pharmaceutical products. Commercially available TSE provide the great Lexibility required for effective continuous mode of operation. The schematic of such a system is shown in Figure 23.6. The twin-screw extruder... 

Otsuka, M. Hasegawa, H. Matsuda, Y., Effect of polymorphic transformation during the extrusion-granulation process on the pharmaceutical properties of carbamazepine granules Chem. Pharm. Bull. 1997, 45, 894-898. 

One of the major drawbacks of liposomes is related to their preparation methods [3,4]. Liposomes for topical delivery are prepared by the same classic methods widely described in the literature for preparation of these vesicles. The majority of the liposome preparation methods are complicated multistep processes. These methods include hydration of a dry lipid film, emulsification, reverse phase evaporation, freeze thaw processes, and solvent injection. Liposome preparation is followed by homogenization and separation of unentrapped drug by centrifugation, gel filtration, or dialysis. These techniques suffer from one or more drawbacks such as the use of solvents (sometimes pharmaceutically unacceptable), an additional sizing process to control the size distribution of final products (sonication, extrusion), multiple-step entrapment procedure for preparing drug-containing liposomes, and the need for special equipment. 

The analogous large-volume series ZSK MEGAvolume with 8.7 Nm/cm3, a diameter ratio of 1.8, and screw speeds of up to 1800 rpm is used for compounds with a high solid matter content, such as those often found in the chemical/food/pharmaceutical industries. The maximum speeds of up to 1800 rpm are used mainly for low-viscosity products, such as pressure-sensitive adhesives and silicon sealants because they provide better elastomer and filler dispersion. Other processes often require large volume only and operate at very moderate speeds of 100 to 600 rpm to protect the product or for direct extrusion into films, sheets, or profiles. 

Typical applications for products and processes with high and low torque requirement are shown in Fig. 14.9. Typical uses of high torques are reinforcing and alloying of engineering plastics and compounding and pelletizing of polyolefin powders into polyolefin pellets, or direct extrusion of films. Low torques are used for products that are shear-sensitive or difficult to feed, such as those often found in the chemical/food/pharmaceutical industries. 

Processing PCTFE is by the conventional methods (extrusion, injection, etc.) processing temperatures are high, and any degradation of PCTFE can cause severe corrosion and environmental problems. Applications include wire and cable insulation, electronic flexible printed circuits, packaging material (transparent film and sheet), pharmaceutical industry in particular strip and blister packs for tablets and capsules, etc. In the chemical industry, used as gaskets, 0-rings, valve seats, chemical tank liners, etc. 

The blow/fill/seal process is a complete packaging technique that integrates the extrusion or IBM and container filling steps. This can provide for aseptic filling of the hot as-blown container and is used for pharmaceutical, food, and cosmetic products. The process employs a two-part mold in which the container body mold cavity blocks are separate from the neck-forming members. 

Alpha Packaging manufactures botdes and jars made from polyethylene terephthalate (PET) and high-density polyethylene (HDPE) for the pharmaceutical, nutritional and personal care markets. Technologies used include injection blow moulding, injection stretch blow moulding, and extrusion blow moulding. Alpha manufactures stock and custom containers in a variety of styles and colours. 

Bomatic, Inc. has been a producer of plastic bottles and containers since 1969. The company serves the personal care, automotive, pharmaceutical, medical, lawn and garden, food, household cleaners, and industrial chemicals markets. Production capabilities include extrusion blow moulding and injection moulding products made from HDPE, PVC, LDPE, PET, PETG, polycarbonate, polystyrene, polypropylene, and polyurethane. 

Gandhi, R., Kaul, C. L., and Panchangula, R. (1999), Extrusion and spheronization in the development of oral controlled-release dosage forms, Pharmaceutical Science and Technology Today, 2,160-170. 

O Connor, R. E., and Schwartz, J. B. (1989), Extrusion and spheronization technology, in Pharmaceutical Pelletization Technology, Marcel Dekker, New York, pp. 187-215. 

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