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Extemporaneous preparation stability

Quercia RA, Fan Cr Liu X, etaf. Stability of omeprazole in an extemporaneously prepared oral liquid Am J Health SystPharm 1997 54 1833-1836 and Dunn A, White M, Reddy P, et al Delivery of omeprazole and lansoprazole granules through a nasogastric tube in vitro. Am J Health Syst Pharm 1999 56 2327-2330. [Pg.675]

Quercia et al. [171] studied the stability of omeprazole 2 mg/ml in an extemporaneously prepared oral liquid. The contents of five 20-mg omeprazole capsules were mixed with 50 ml of 8.4% sodium bicarbonate solution in a Luer-Lok syringe. Three vials of this liquid were prepared for storage at 24,5, and — 20 °C. A 3-ml sample of each was taken initially and on days 1, 2, 3, 4, 6, 8, 10, 12, 14, 18, 22, 26, and 30 and assayed by HPLC. The liquids stored at 5 and — 20 °C did not change color during the study period, but the color of the liquid stored at 24 °C changed from white to brown. [Pg.251]

Stability Aspects of Radiopharmaceuticals 1.3.6 Extemporaneous Preparation of Radiopharmaceuticals... [Pg.60]

Emulsifying agents are used both to promote emulsification at the time of manufacture and to control stability during a shelf life that can very from days for extemporaneously prepared emulsions to months or years for commercial preparations. In practice, combinations of emulsifiers rather than single agents are used. The emulsifier also influences the in vivo fate of lipid parenteral emulsions by its influence on the surface properties of the droplets and on the droplet size distributions. For convenience, most pharmacy texts classify emulsifiers into three groups i) surface active agents ii) natural (macromolecular) polymers and hi) finely divided solids. [Pg.1551]

The inhalation of antimicrobial agents to treat infections in the lung has been of interest for decades [1], As early as the 1950s, extemporaneously prepared antimicrobial agents were aerosolized to treat pneumonia. These preparations were often crude and not well tolerated by patients. Dosage, formulation procedures, and stability assessment in these early reports were not consistent. Although some successes were reported, the potential benefit of this route of administration was not fully appreciated until the 1980s. [Pg.486]

It can take many months to develop an acceptable DPI or pMDI for early clinical studies, but an expeditious route is to use an extemporaneously prepared nebuliser solution of the drug and a matching placebo. This can be developed relatively quickly with only 24 h stability... [Pg.372]

Yamreudeewong, W. Lopez-Anaya, A. Rappaport, H. Stability of fluconazole in an extemporaneously prepared oral liquid. Am.J.Hosp.Pharm., 1993, 50, 2366-2367 [methyl p-hydroxybenzoate (IS) stability-indicating]... [Pg.620]

Among single drug component studies, usual vehicles for dilution are 5% dextrose (D5W), 0.9% sodium chloride (normal saline, NS), aqueous buffers, peritoneal dialysis fluid, nonaqueous solvents, water for injection, phosphate-buffered saline, bacteriostatic water for injection, bacteriostatic sodium chloride. Ringer s injection, and lactated Ringer s. Stability studies can also be carried out on the drug product solution as such or in specific containers or injection devices. Solutions and suspensions can also be prepared extemporaneously and stability tested to show worthiness for oral, ophthalmic, or rectal administration. The following is an example of the first... [Pg.2727]

The limited stability of the dienophiles used in these studies demands their extemporaneous preparation by oxidation of the corresponding catechols with... [Pg.100]

Regarding Compatibility if components of a prescribed preparation are not compatible (or there is a lack of evidence), it does not mean automatically that it should not be prepared. The preparation needs to show sufficient compatibility up to the in use expiry date it may be possible to produce a preparation with a shortened but useful shelf life. Interactions between the active substances and excipients can however make it impossible to produce a preparatiOTi of sufficient quality. These incompatibilities can be visible or invisible during preparation. The attending pharmacist has to verily if incompatibilities are apparent. More informaticHi about incompatibilities is to be found in references such as Fiedler (Sect. 39.2.2), Handbook of Pharmaceutical Excipients (Sect 39.2.3), Martindale (Sect. 39.2.4), Handbook of Extemporaneous Preparation (Sect. 39.4.6), Konunentar zum Arzneibuch (Sect. 39.4.8) and Trissel s Stability of Compounded Formulations (Sect. 39.4.14). [Pg.13]

Al-Badriyeh D, Li J, Stewart K et al (2009) Stability of extemporaneously prepared vOTiconazole ophthalmic solution. Am J Health-Syst Pharm 66 1478-83... [Pg.187]

Suppositories prepared as extemporaneous preparations following a non-standardised formula, having an unknown chemical or physical stability, should immediately be dispensed to the patient who gets a maximal usage period of 1 month only (see Sect. 22.7.2) if classified as semisolid preparation. If the patient only takes a suppository on demand a usage period of 1 month is very short and it may be justified to consider fiiem to be comparable to a dry dosage form with an arbitrarily chosen maximum usage period of 6 months. [Pg.203]

To get an idea of the stability of an extemporaneous preparation the only possibility is to keep a part of the preparation in the pharmacy in order to be able to recall if necessary or to have some information in case of a second prescription. For background information on the instability of disperse systems (suspensions, emulsions) and the ways to overcome those stability problems, see Sect. 18.4. For a useful review about the changes in dissolution rate during shelf life and how to prevent them, reference is made to [4]. [Pg.436]

Extemporaneous preparations, with unknown or uncertain chemical or physical stability, carmot be kept on stock in the pharmacy. They have a maximum usage period according to Table 22.15, but this period is not more than 1 month for liquid and semisolid preparations, and not more than 6 months for dry forms. If the formula is similar to a standardised one, the maximum shelf life of that standardised formula can be used. [Pg.457]

For more extensive information on substances several sources can be useful. Profiles of drug substances excipients and related microbiology. Handbook on extemporaneous preparation and Trissel s Stability of compounded formulations are discussed. [Pg.843]

This handbook has a part on standards for extemporaneous dispensing and a part containing stability summaries for the 50 most frequent extemporaneously prepared medicines in UK NHS hospitals. It also includes sections relating to clinical risk assessment and advice for procuring tmlicensed medicines from manufacturers. [Pg.844]

Abdel-Rahman, S.M. Nahata, M.C. Stability of famagRlin in an extemporaneously prepared ophthalmic... [Pg.288]

For products that are prepared extemporaneously at a regular basis or even for a limited stock, a product specific documentation (product file) is needed. This will include specifications, instructions, and records but also a pharmaceutical assessment of safety data, toxicity, biopharmaceutical aspects, stability, and product design. The product file should also include a product review as soon as a product is used repeatedly or over longer periods. [Pg.94]


See other pages where Extemporaneous preparation stability is mentioned: [Pg.1009]    [Pg.1010]    [Pg.684]    [Pg.608]    [Pg.1359]    [Pg.53]    [Pg.55]    [Pg.608]    [Pg.36]    [Pg.51]    [Pg.201]    [Pg.245]    [Pg.2629]    [Pg.656]    [Pg.92]    [Pg.552]    [Pg.167]   
See also in sourсe #XX -- [ Pg.155 , Pg.454 ]




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Extemporaneous preparation

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