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Stability control

A dossier that focuses on quality (manufacture, control, stability) and labelling of the product must be submitted in support of the application. [Pg.162]

Figure 31 demonstrates the combined controller response to a demand disturbance. The proportional action of the controller stabilizes the process. The reset action combined with the proportional action causes the measured variable to return to the setpoint. The rate action combined with the proportional action reduces the initial overshoot and cyclic period. [Pg.153]

When the column temperature is set to a near ambient temperature, external air is brought into the oven via a computer-controlled flap, providing rigid temperature control stability. (The lowest controllable column temperature is 24°C when the ambient temperature is 18°C and the injection port temperature is 250°C. The temperature fluctuation is less than 0.1 °K even when the column temperature is set at 50°C. [Pg.65]

In-Process Testing Packaging and Labeling of Finished BPC Expiration Dating or Reevaluation Dating Laboratory Controls Stability Testing... [Pg.327]

HPLC is a complex analytical methodology that involves the development of a unique method for each new application. This method development often requires the optimisation of several method conditions to achieve a desired selectivity and sensitivity [12,13]. HPLC is also one of the most commonly applied analytical techniques and is in widespread use throughout the pharmaceutical industry for applications as diverse as quality control, stability studies and clinical trials. These two reasons mean that HPLC has been the focus of most research into ruggedness testing procedures because it is most likely to require extensive ruggedness... [Pg.198]

Strained hydrocarbons range from being quite stable thermally and relatively unreactive (cyclobutane) to being transient intermediates. The following will be concerned with the factors that control stability and reactivity. [Pg.718]

McClements, D.J., Decker, E.A., Park, Y., Weiss, J. (2008). Designing food structure to control stability, digestion, release and absorption of lipophilic food components. Food... [Pg.75]

Electroless solutions contain a metal salt, a reducing agent, a pH adjuster or buffer, a complexing agent, and one or more additives to control stability, film properties, deposition rates, etc. [Pg.106]

Izumrudov, V.A., Zhiryakova, M.V. and Kudaibergenov, S.E. (1999) Controllable stability of DNA-containing polyelectrolyte complexes in water-salt solutions. Biopolymers, 52, 94-108. [Pg.353]

In general, in the academic literature on Colloid Science, the latter states are regarded as an end-product and the main emphasis in research has been directed towards understanding the factors which control stability. However, in the technological application of latices, it is often material in the flocculated state which is utilised in order to obtain the desired flow properties. In fact, in order to focus attention on the question of floe structure and pursue this topic further, we must ask a series of questions -... [Pg.61]

Similar to complaint trends, internal audit information that reveals recurring noncompliance patterns related to such product-specific activities as manufacturing, process controls, stability testing, and operator performance should alert QA of the possibility this may have on released product. The key is to intercept the product before it is released and a recall is demanded. [Pg.537]

Flocculation in O/W systems provides a means to control stability and texture, and can be produced through several mechanisms [817] ... [Pg.305]

Whenever a sample has to be brought to an analyzer, a transportation delay and a potential for interference with the integrity of the sample are inevitable. If an automatic controller maintains the measured composition, the transportation lag can seriously deteriorate the closed-loop control stability of the loop. An even more serious consequence of the use of sampling systems is the potential for interference with the integrity of the sample. This can occur due to filtration, condensation, leakage, evaporation, and so on, and these operations cannot only delay, but also change information and measurement. [Pg.330]

Understanding and controlling stability is a critical issue for display applications. A simple bias stress test (Vg = —40 V, Vos = —40 V) was conducted on pentacene TFTs for different times. Figure 15.14 shows the TFT characteristics before and after the bias stress. A few volts shift is observed in the threshold potential after a 20-min bias stress. [Pg.383]

The implementation of the above distributed controllers stabilizes the fast dynamics and affords us the opportunity to carry out a numerical experiment Figure 3.7 shows the evolution of the product purity x2y, for the original system with the above proportional stabilizing controllers and starting from an initial condition slightly perturbed from the nominal steady state. Clearly, x2y, exhibits an initial fast transient ( boundary layer ) followed by a slow dynamics, highlighting the two-time-scale behavior of this process. [Pg.55]

Aggregates like polyelectrolyte complexes having positive charges and hydrophobic domains show a broader optimum flocculation concentration range and are considered as new reactive nanoparticles [11-14], Thus, polycations with hydrophobic functionalities represent an interesting class of water-soluble associating polyelectrolytes relevant for controlled stabilization/flocculation of dispersions in numerous industrial applications. [Pg.103]

The use of PID controllers should be restricted to those loops where two criteria are both satisfied the controlled variable should have a very large signal-to-noise ratio and tight dynamic control is really essential from a feedback control stability perspective. The classical example of the latter is temperature control in an irreversible exothermic chemical reactor (see Chap. 4). [Pg.59]

Modem circulating baths are digital, and even programmable in some cases, with PRT sensors and PID control. They can achieve control stability of 0.01°C (even 0.005°C for the best ones) over the range 20 to 200°C without refrigeration units. These baths are easy to use, and no detailed information on their operation is given here. However, there are mai r simpler baths with manually set thermoregulators and proportional controllers. [Pg.584]

Emulsifying agents are used both to promote emulsification at the time of manufacture and to control stability during a shelf life that can very from days for extemporaneously prepared emulsions to months or years for commercial preparations. In practice, combinations of emulsifiers rather than single agents are used. The emulsifier also influences the in vivo fate of lipid parenteral emulsions by its influence on the surface properties of the droplets and on the droplet size distributions. For convenience, most pharmacy texts classify emulsifiers into three groups i) surface active agents ii) natural (macromolecular) polymers and hi) finely divided solids. [Pg.1551]

Therefore, admixture studies are performed on parenteral drugs with commonly used intravenous diluents. Studies are performed by preparing admixtures of the drug product with various diluents in an appropriate type of flexible intravenous bag. Initial samples are taken for analysis before the bags are stored in temperature-controlled stability chambers. Subsequent samples may be pulled at 6-, 12-, 24-, 48-, and 72-h time points. The analytical tests commonly performed include visual appearance, pH, and HPLC assay. Degradation products are not commonly tested unless the method has been previously evaluated for specificity and stability-indicating ability with a particular intravenous diluent. This is necessary because there may be differences in the stability profile of the product in its original formulation compared to the admixture solution. Formation of any particulate matter is detected by visual... [Pg.282]

The transfer function for derivative control is sTd, and the frequency response characteristics are a phase angle of +90° and an amplitude ratio of a)Td. Control stability results from the leading phase angle. [Pg.60]


See other pages where Stability control is mentioned: [Pg.1838]    [Pg.114]    [Pg.738]    [Pg.494]    [Pg.43]    [Pg.216]    [Pg.448]    [Pg.548]    [Pg.39]    [Pg.402]    [Pg.251]    [Pg.16]    [Pg.9]    [Pg.194]    [Pg.215]    [Pg.1597]    [Pg.215]    [Pg.148]    [Pg.202]    [Pg.337]    [Pg.1268]    [Pg.977]    [Pg.1516]    [Pg.360]    [Pg.548]    [Pg.2297]    [Pg.417]    [Pg.162]    [Pg.339]   
See also in sourсe #XX -- [ Pg.475 , Pg.484 ]




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