Ethacridine lactate

Common Name Acrinoli lactas Aethacridinlactat Etacridin Etakridin Ethacridine lactate Lactacridine... 

Guo, Z.Y. et al. HPLC method for the determination of ethacridine lactate in human urine. Biomed. Chromatogr. 2007, 21,480-483. 

Dose. Ethacridine lactate has been given, by mouth, in doses of 200 to 600 mg daily. 

Dihydralazine Sulphate Oxyphenisatin Acetate Proguanil Hydrochloride Ethacridine Lactate... 

Etafedrine hydrochloride, 589 Etamiphylline, 590 Etamiphylline camsylate, 590 Etamivan, 593 Etamphyllin, 590 Etamyl, 353 Etaphylline, 310 Etebenecid, 595 Etenzamide, 590 Ethacridine, 591 Ethacridine lactate, 591 Ethacrynate sodium, 591 Ethacrynic acid, 591 Ethambutol, 592 Ethambutol hydrochloride, 592 Ethamide, 602 Ethaminal sodium, 863 Ethamivan, 593 Ethamolin, 594 Ethanal, 311 Ethanediol, 603 Ethanol, 593 assay kit, 1171 quantification, 19 Ethanol, denatured, 593 Ethanolamine, 594... 

In 56 women (18-20 weeks gestation), treated at the Marie Stopes Chnic in Jodhpur, India, who underwent termination of pregnancy with 0.1% ethacridine lactate 150 ml injected into the intrauterine extra-amniotic space and in whom intravenous oxytocin was used to expedite the dehvery of the abortus, ethacridine lactate induced successful abortion in 52 cases (1). Abortion failure occurred in the other four cases because of transverse lie of fetus (n = 2), cervical dystocia (n = 1), and uterine inertia (n = 1). In 41 women the abortion occurred at 12-24 hours after induction (mean 20 hours) which was shorter than that of previous reports (29.5-38 hours). There were complications in six cases three women had cervical tears and three had incomplete expulsion. There was one case each of severe bleeding and vaginal laceration. There were no cases of sepsis. The authors concluded that ethacridine lactate performed better than other instillation abortion methods. 

In a prospective, placebo-controUed study, tannin albuminate 500 mg plus ethacridine lactate 50 mg was given to 30 patients with Crohn s disease and chronic diarrhea for 5 days, followed by a 5-day break, and then a further 5 days treatment (2). Stool frequency was significantly reduced, albeit by only a small amount, with an improvement in the consistency of the stools. 

Gupta S, Sachdeva L, Gupta R. Ethacridine lactate—a safe and effective drug for termination of pregnancy. Indian J Matern Child Health 1993 4(2) 59-61. 

Plein K, Burkard G, Hotz J. Behandlung der chronischen Diarrhoe beim Morbus Crohn. Eine Pilotstudie zur kUnischen Wirkung von Tanninalbuminat und Ethacridinlactat. [Treatment of chronic diarrhea in Crohn disease. A pilot study of the clinical effect of tannin albuminate and ethacridine lactate.] Fortschr Med 1993 111(7) 114-18. 

Table 2 Impact of aqueous environment and drug loading with ethacridine lactate (EL) and enoxacine (EN) on key shape memory properties from stress-controlled experiments and on the thermal transition of an amorphous oLG tetrole derived SMP network. Modified from [30]. Copyright 2009, with permission from Elsevier...

Fig. 10 Degradation characteristics of oLG tetrole derived SMP depending on the absence or presence of ethacridine lactate (EL), enoxacine (EN) and nitrofurantoin (ME), (a) Loss of relative sample mass /Xrei over time due to removal of water soluble degradation products, (b) Water uptake of samples, (c) Changes in gel content G and degree of swelling Q. (d) Alteration of the elastic modulus E (Young s modulus) of wet materials as determined by tensile tests at 37 °C in water. Reprinted from [30]. Copyright 2009, with permission from Elsevier...

Treatment of sodium nitroprusside with ethacridine lactate (I) pelds a yellow, almost insoluble precipitate of l2Fe(CN)sNO. This reaction is applicable as a spot test for nitroprussides. 

Procedure. A drop of the test solution is mixed with a drop of an ethacridine lactate solution in a micro test tube. A yellow precipitate or turbidity indicates the presence of nitroprusside. 

Diverse organic compounds may be determined by indirect iodometry. We give only one example here, that of ethacridine lactate, whose determination is described in the european pharmacopeia. 

The compound is precipitated by an excess of a standardized solution of potassium bichromate. The excess bichromate is titrated by adding sodium iodide. The liberated iodine is titrated by thiosulfate. Thus, the quantitative reaction exhibited by ethacridine lactate is not a redox reaction. It is a precipitation reaction. 

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