Estrogen metabolites

Ahel M, Molnar E, Ibric S, Giger W (2000) Estrogenic metabolites of alkylphenol polyethoxylates in secondary sewage effluents and rivers. Water Sci Technol 42 15-22... [Pg.103]

Estriol (estra-1,3,5(10)-trien-3,16-a,17-8 -triol) is the major estrogen metabolite found in the urine. It is excreted in the form of its conjugate with glucuronic acid. The determination of this steroid as an index of placental function has become one of the most widely used endocrine determinations. As pregnancy progresses, the excretion increases and reaches very high levels near term. In abnormal fetoplacental function, the levels of estriol will fall in some cases. The fall is usually progressive, and, because of this, serial determinations of urinary estriol must be carried out. The drop in estriol can be taken as evidence of placental insufficiency, and close watch by the physician is indicated, as a continued drop may necessitate Cesarean section to save the life of the infant. [Pg.499]

Haggans, C.J., Hutchins, A.M., and Olson, B.A. 1999. Effect of flaxseed consumption on urinary estrogen metabolites in postmenopausal women. Nutr. Cancer 33, 188-195. [Pg.83]

Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst 1997 89 718-723. [Pg.191]

Xu X, Roman JM, Issaq HJ, Keefer LK, Veenstra TD, Ziegler RG (2007) Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. Anal Chem 79 7813-7821... [Pg.279]

Taioli E, Im A, Xu X, Veenstra TD, Ahrendt G, Garte S (2010) Comparison of estrogens and estrogen metabolites in human breast tissue and urine. Reprod Biol Endocrinol 8 93-99... [Pg.280]

Knust U, Strowitzki T, Spiegelhalder B, Bartsch H, Owen RW (2007) Optimization of an isotope dilution gas chromatography/mass spectrometry method for the detection of endogenous estrogen metabolites in urine samples. Rapid Commun Mass Spectrom 21 2245-2254... [Pg.281]

Nguyen HP, Yang SH, Wigginton JG, Simpkins JW, Schug KA (2010) Retention behavior of estrogen metabolites on hydrophilic interaction chromatography stationary phases. J Sep Sci 33 793-802... [Pg.281]

Xu X, Roman JM, Veenstra TD, Van Anda J, Ziegler RG, Issaq HJ (2006) Analysis of fifteen estrogen metabolites using packed column supercritical fluid chromatography-mass spectrometry. Anal Chem 78 1553-1558... [Pg.283]

Xu X, Othman ER, Issaq HJ, Hornung D, Al-Hendy A, Veenstra TD (2008) Multiplexed quantitation of endogenous estrogens and estrogen metabolites in human peritoneal fluid. Electrophoresis 29 2706-2713... [Pg.284]

Xu X, Keefer LK, Ziegler RG, Veenstra TD (2007) A liquid chromatography-mass spectrometry method for the quantitative analysis of urinary endogenous estrogen metabolites. Nat Protoc 2 1350-1355... [Pg.284]

During the first half of the twentieth century, when 87,000 people died from pellagra in the United States, there was a two-fold excess of females over males. Reports of individual outbreaks of pellagra show a similar sex ratio. This may well be the result of inhibition of kynureninase, and impairment of the activity of kynurenine hydroxylase, by estrogen metabolites, and hence reduced synthesis of NAD from tryptophan (Bender and Totoe, 1984b). [Pg.213]

As discussed in Section 8.3.3, estrogen metabolites inhibit kynureninase and reduce the activity of kynurenine hydroxylase to such an extent that, even without induction of tryptophan dioxygenase (Section 9.5.4.1), the activity of these enzymes is lower than is needed for the rate of flux through the pathway, thus leading to increased formation of xanthurenic and kynurenic acids. [Pg.254]

As discussed in Section 9.5.4.2, estrogen metabolites inhibit kynureninase, and they also lead to reduced activity of kynurenine hydroxylase. As a result, in pregnancy or in response to (high-dose) oral contraceptives, tissue concentrations of kynurenine, hydroxykynurenine, xanthurenic, and kynurenic acids are higher than normal. [Pg.263]

Dehydroepiandrosterone has demonstrated efficacy in the improvement of mood, interest, confidence, and anxiety levels in various populations. In a recent clinical trial, it has been reported to be useful in the treatment of negative, depressive, and anxiety symptoms of schizophrenia,and in another trial, DHEA and its metabolites produced a positive effect overall on recognition memory in postmenopausal women. In fact, estrogen metabolites of DHEA had produced a positive effect on recognition memory, while androgen metabolites produced a negative effect. This pattern reversed in perceptual identification. ... [Pg.2440]

Hirshman, E. Merritt, P. Wang, C.C.L. Wierman, M. Budescu, D.V. Kohrt, W. Templin, J.L. Bhasin, S. Evidence that androgenic and estrogenic metabolites contribute to the effects of dehydroepiandrosterone on cognition in postmenopausal women. Horm. Behav. 2004, 45 (2), 144-155. [Pg.2449]

Chen C, Malone KE, Prunty J, Daling JR. Measurement of urinary estrogen metabolites using a monoclonal enzyme-linked immunoassay kit Assay performance and feasibility for epidemiological studies. Cancer Epidemiol Biomarkers Prev 1996 5 727-32. [Pg.2141]

Estrogen metabolites APCI + Diol/Cyanopropyl/columns... [Pg.283]

FIGURE 9.8 (a) HPLC separation of the 15 estrogen metabolites using a RP C-18 column... [Pg.288]

Zearalenone (ZEN), known as F2 toxin,is a non-steroidal estrogenic metabolites produced by Fusarium species, and was isolated by Christensen et. al. from a culture of Fusarium. Urry et. al. elucidated the chemical structure of... [Pg.340]

E., A new estrogen metabolite formed by the human fetus and newborn. Excerpta Med. Intern. Congr. Ser. Ill, 291 (1966). [Pg.215]

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