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Epilepsy evaluation

The mechanisms involved have been assessed in 40 women with epilepsy evaluated before and after 1 year of therapy (1166). At the end of follow-up, 15 patients were obese and had higher serum leptin and insulin concentrations than patients who did not gain weight. The rise in serum leptin is consistent with that observed in other types of obesity. [Pg.654]

How the different neurotransmitters may be involved in the initiation and maintenance of some brain disorders, such as Parkinson s disease, epilepsy, schizophrenia, depression, anxiety and dementia, as well as in the sensation of pain, is then evaluated and an attempt made to see how the drugs which are used in these conditions produce their effect by modifying appropriate neurotransmitter function (section C). The final section (D) deals with how neurotransmitters are involved in sleep and consciousness and in the social problems of drug use and abuse. [Pg.1]

M. Bialer, L. Arcavi, S. Sussan, A. Volosov, A. Yacobi, D. Morus, B. Levitt, and A. Laor, Existing and new criteria for bioequivalence evaluation of new controlled release products of carbamazipine, Epilepsy Res., 32, 371 (1998). [Pg.759]

PET scans with 18F-fluorodeoxyglucose (18F-FDG) have an established role in the localization of epileptic foci in patients being evaluated for epilepsy surgery. [Pg.949]

Hetherington, H. P., Kuzniecky, R, I., Pan, J. W. et al. Application of high field spectroscopic imaging in the evaluation of temporal lobe epilepsy. Magn. Reson. Imaging 13 1175-1180,1995. [Pg.958]

Treatment of epilepsy is often more complex in the elderly (Tallis et al. 2002). Plasma concentration of antiepileptic drugs that are adequate for younger patients may be toxic for older adults. Clinical response, and not only plasma concentration of the drug, is more important in the elderly for evaluation of antiepileptic treatment. [Pg.17]

Several other herbs have weaker evidence for CNS depressant effects, but hold potential for further research and evaluation. Certain herbs have also had historical use for treating epilepsy, before the invention of several modern, very effective synthetic antiseizure medications. There is, at present, absolutely no evidence that the CNS depressant herbs will be effective or sufficient in the treatment of epilepsy. Much further research would be needed to support this contention. Further, withdrawal of current antiseizure medications would put an individual at high risk for recurrence or worsening of seizures. [Pg.246]

Kastner et al. (1993) evaluated valproic acid in 18 children and adults (mean age, 19.7 years) with self-injury or aggression, irritability, sleep disorder, and evidence of cycling. Fourteen (78%) responded positively as assessed by the CGI in this uncontrolled study. The authors found that 11 subjects with established or suspected epilepsy responded significantly better than participants with no evidence of epilepsy. [Pg.622]

From a clinical perspective, some of these PCO classes have attracted initial attention. Diazoxide and minoxidil have been evaluated as antihypertensive agents. These PCOs open K+ channels in the plasma membranes of vascular smooth muscle cells, causing vascular vasodilation, thereby lowering blood pressure. Cromakalim has been investigated as a smooth muscle bronchodilator for the treatment of human asthma. Nicorandil was launched in Japan in 1984 for the treatment of angina because of its perceived ability to promote vasodilation of coronary arteries. Developmental work on these and other PCOs is continuing for indications ranging from hypertension, asthma, urinary incontinence, psychosis, epilepsy, pain, and alopecia (hair loss). [Pg.424]

Cost-effectiveness is an economic evaluation in which both the costs and the consequences of treatments are examined. The denominator of the cost-effectiveness ratio can be an intermediate outcome, such as a delay in the progression of a disease, or a final outcome, such as life-years saved. Once the outcome is measured, the costs associated with attaining this outcome form the numerator of the ratio. For example, suppose our interest is determining the relative value of drug therapy for epilepsy versus epilepsy... [Pg.308]

Table 5-27 and Table 5-28 summarize the clinically relevant pharmacokinetic and pharmacodynamic properties of other novel antipsychotics ( 326). Drug interactions with these agents were not systematically evaluated because controlled clinical trials usually prohibit concurrent medications. There are also many special circumstances (e.g., patients with comorbid medical diseases, substance abuse, epilepsy, or atypical indications such as agitation associated with mental retardation or dementia) that are not usually addressed in clinical research trials. Thus, much remains to be learned about significant drug interactions in these patient groups. To our knowledge, however, no consistent, serious, clinically relevant interactions have been reported. [Pg.92]

Ueberall MA. Normal growth during lamotrigine monotherapy in pediatric epilepsy patients—a prospective evaluation of 103 children and adolescents. Epilepsy Res 2001 46(l) 63-7. [Pg.674]

Gidal BE, Sheth R, Parnell J, et al. Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics implications for conversion to lamotrigine monotherapy. Epilepsy Res 2003 57 85-93. [Pg.357]

In 10 children with rolandic epilepsy, carbamazepine impaired memory and possibly visual search tasks (122). Evaluation of individual data suggested that some children were especially vulnerable to the adverse effects of carbamazepine on cognition. The authors did not comment on the fact that rolandic epilepsy is regarded as a syndrome for which treatment in most cases is not indicated. [Pg.656]

The routine drug management of epilepsy by community health nurses without prior training in epilepsy management has been evaluated by neurologists in Zimbabwe (182). Of 114 patients (aged 8-56 years, 84% with generalized seizures), 40% had been seizure-free for at least 6 months ... [Pg.296]

Adamolekun B, Mielke J, Ball D, Mundanda T. An evaluation of the management of epilepsy by primary health care nurses in Chitungwiza, Zimbabwe. Epilepsy Res 2000 39(3) 177-81. [Pg.301]

Sachdeo RC, Narang-Sachdeo S, Montgomery PA, Shumaker RC, Perhach JL, Lyness WH, Rosenberg A. Evaluation of the potential interaction between felbamate and erythromycin in patients with epilepsy. J Chn Pharmacol 1998 38(2) 184-90. [Pg.1242]

The efficacy and safety of lamotrigine have been prospectively evaluated in 41 children and yonng adults (aged 3-25 years) with drug-resistant partial epilepsies (8). Lamotrigine withdrawal was mainly due to lack of efficacy (46%) only two patients developed a transient skin rash, which did not require withdrawal. [Pg.1991]

Gidal BE, Walker JK, Lott RS, Shaw R, Speth J, Marty KJ, Rutecki P. Efficacy of lamotrigine in institutionalized, developmentally disabled patients with epilepsy a retrospective evaluation. Seizure 2000 9(2) 131-6. [Pg.1999]


See other pages where Epilepsy evaluation is mentioned: [Pg.50]    [Pg.346]    [Pg.235]    [Pg.525]    [Pg.207]    [Pg.939]    [Pg.388]    [Pg.74]    [Pg.307]    [Pg.123]    [Pg.645]    [Pg.645]    [Pg.98]    [Pg.201]    [Pg.334]    [Pg.580]    [Pg.614]    [Pg.654]    [Pg.115]    [Pg.35]    [Pg.495]    [Pg.298]    [Pg.759]    [Pg.759]    [Pg.274]    [Pg.279]    [Pg.284]    [Pg.1993]   
See also in sourсe #XX -- [ Pg.1046 ]




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Epilepsies

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