Epidermal growth factor modules

Reinhardt, D. P., Ono, R. N., Notbohm, H., Muller, P. K., Bachinger, H. P., and Sakai, L. Y. (2000a). Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis. A potential disease-causing mechanism in Marfan syndrome. / Biol. Chem. 275, 12339-12345. 

Westermark, K., Karlsson, F.A., Westermark, B., 1983, Epidermal growth factor modulates thyroid growth and function in culture, Endocrinology 112 1680. 

FIGURE 6.38 A sampling of proteins that consist of mosaics of individual protein modules. The modules shown include 7CG, a module containing 7-carboxyglutamate residues G, an epidermal growth-factor-like module K, the kringle domain, named for a Danish pastry ... 

Figure 47-10. Schematic diagram of the structure of human L-selectin. The extracellular portion contains an amino terminal domain homologous to C-type lectins and an adjacent epidermal growth factor-like domain. These are followed by a variable number of complement regulatory-like modules (numbered circles) and a transmembrane sequence (blackdiamond). A short cytoplasmic sequence (open rectangle) is at the carboxyl terminal. The structures of P- and E-selectin are similar to that shown except that they contain more complement-regulatory modules.The numbers of amino acids in L-, P-, and E- selectins, as deduced from the cDNA sequences, are 385,789, and 589, respectively. (Reproduced, with permission, from Bevilacqua MP, Nelson RM Selectins. J Clin Invest 1993 91 370.)...

Wiley, H. S., Walsh, B. J. and Lund, K. A. (1989). Global modulation of the epidermal growth factor is triggered by occupancy of only a few receptors evidence for a binary regulation system in normal human fibroblasts, J. Biol. Chem., 264, 18 912-18 920. 

Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999 59 1935-1940. 

Huang SM, Harari PM. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin Cancer Res 2000 6 2166-2174. 

Boockvar, J.A., Schouten, J., Royo, N., Millard, M., Spangler, Z., Castelbuono, D., Snyder, E., O Rourke, D., McIntosh, T. (2005). Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells. Neurosurgery, 56,163-71. 

Schroder and co-workers (Schroder etal., 1999,2000) studied PolyP metabolism in bone tissues and osteblast cultures. They revealed that PolyP metabolism in human osteoblasts was modulated by stimulators of osteoblast proliferation and differentiation (Leyhausen et al., 1998). A combined treatment of the cells with dexamethasone, ft-glycerophosphate, epidermal growth factor (EGF), and ascorbic acid resulted in a dramatic decrease in PolyP content. This decrease is caused mainly by a decrease in the amount of soluble long-chain PolyPs. The amount of this PolyP fraction, but not the amount of insoluble long-chain PolyPs, further decreases after additional treatment of the cells with la, 25-dihydroxy vitamin D3. The decrease in PolyP content during treatment with dexamethasone, ft-glycerophosphate, EGF and ascorbic acid is accompanied by a decrease in exopolyphosphatase activity. However, additional treatment with la, 25-dihydroxyvitamin D3 results in a significant increase of the enzyme activity. Therefore, it is reasonable to assume that PolyP... 

Schuurmans, A. L., Bolt, J., and Mulder, E., Androgens and transforming growth factor beta modulate the growth response to epidermal growth factor in human prostatic tumor cells (LNCaP). Mol. Cell. Endocrinol. 60, 101-104 (1988). 

Stetefeld, J., Mayer, U., Timpl, R., and Huber, R. (1996). Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin 7I chain harboring the nidogen binding site. J. Mol. Biol. 257, 644-657. 

Wattenberg, E.V, McNeil, P.L., Eujiki, H., and Rosner, M.R. 1989. Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway. J Biol Chem 264, 213-219. 

Vella, F., Hernandez, J.-F., Molla, A., Block, M. R., and Arlaud, G. J. (1999) Grafting an RGD motif onto an epidermal growth factor-Uke module chemical synthesis and functional characterization of the chimeric molecule. J. Pept. Res. 54, 415-426. 

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