Growth-factor module

Canman CE, Gilmer TM, Coutts SB, et al. Growth factor modulation of p53-mediated growth arrest... 

Maldonado PE, Rose B, Loewenstein WR Growth factors modulate junctional cell-to-cell communication. J Membr Biol 1988 106 203-210. 

Reinhardt, D. P., Ono, R. N., Notbohm, H., Muller, P. K., Bachinger, H. P., and Sakai, L. Y. (2000a). Mutations in calcium-binding epidermal growth factor modules render fibrillin-1 susceptible to proteolysis. A potential disease-causing mechanism in Marfan syndrome. / Biol. Chem. 275, 12339-12345. 

Several newer phannacological effects, independent of the anticoagulant effects, have been described. These include glycosylation mediated functional modulation of macromolecules, growth factor modulation, release of endothelial products and interactions with various endogenous sites. 

Satchell SC, Anderson KL, Mathieson PW (2004) Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties. J Am Soc Nephrol 15(3) 566-574... 

Pons, S. and Torres-Aleman, I. (1992) Basic fibroblast growth factor modulates insulin-like growth factor-1, its receptor, and its binding proteins in hypothalamic cell cultures. Endocrinology 131 2271-2278. 

Itoh H, Mukoyama M, Pratt RE, Gibbons GH, Dzau VJ (1993) Multiple autocrine growth factors modulate vascular smooth muscle cell growth response to angiotensin II. J Clin Invest 91 2268-2274... 

G9. Gong, R., Rifai, A., Tolbert, E. M., Centracchio, J. N., and Dworkin, L. D., Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis. J. Am. Soc. Nephrol 14, 3047-3060 (2003). 

Bordoni, R., Thomas, G., and Richmond, A. (1989) Growth factor modulation of melanoma growth stimulatory activity mRNA expression in human malignant melanoma cells correlates with cell growth. J. Cell. Biochem. 39, 421-428. 

Lee, T. H., Avraham, H., Lee, S. H., and Avraham, S. (2002). Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells. J. Biol. Chem. 277, 10445-10451. 

Zhang, YH, Vasko, MR and Nicol, GD (2002) Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. J Physiol, 544, 385—402. 

Reaction of compound 114 with boronic acid 134 resulted in a derivative 2,3-difluoropyridine 135, used as HGF (Hepatocyde Growth Factor) modulators [109] (Scheme 50). 

Westermark, K., Karlsson, F.A., Westermark, B., 1983, Epidermal growth factor modulates thyroid growth and function in culture, Endocrinology 112 1680. 

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