DNA damage repair

There is some evidence that carotenoids (particularly P-carotene) may influence both arms of the DNA damage repair balance (Astley et al., 2002 Pillion et al, 1998). 

Astley, SB, Elliott, RM, Archer, DB, and Southon, S, 2004a. Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage repair balance in human lymphocytes. Br JNutr9l, 63-72. 

APPLICATION TO TUMORS WITH OTHER DNA DAMAGE REPAIR DEFICIENCIES... 

There is an enzymatic mechanism of DNA damage repair, which is responsible for recognition, discharge, and replacement of damaging structures with normal ones. On the other hand, carbon radicals formed on the DNA backbone can be repaired by the interaction with antioxidants. Practically all traditional antioxidants and free radical scavengers have been described to inhibit free radical-mediated DNA damage. 

Ulrich, H. D. Protein-protein interactions in an E2-RING finger complex implications for ubiquitin-dependent DNA damage repair. J. 

In recent years, additional transcription-unrelated roles of Tip60 have emerged. Perhaps most notably, it has been demonstrated to play key roles in a number of nuclear processes involved in DNA damage repair. Efficient and accurate repair of... 

Bradley, M.O. Erickson, L.C. (1981) Comparison of the effects of hydrogen peroxide and X-ray irradiation on toxicity, mutation, and DNA damage/repair in mammalian cells (V-79). Biochim. biophys. Acta, 654, 135-141... 

Second, BrdU was not detected in cells exhibiting features of DNA damage, repair, or programmed cell death. DNA damage was detected using the TUNEL assay. As expected, ischemia increased the number of TUNEL+ cells in several... 

Short-term tests. Tests for point mutations, numerical and structural chromosome aberrations, DNA damage/repair, and in vitro transformation provide supportive evidence of stochastic responses and may give information on potential mechanisms of action. A range of tests for each of the above responses helps to characterize the response spectrum of a substance. 

In cancer, the genes for p53R2 and other components of the DNA damage-repair pathway are often mutated. Cells lacking p53R2 are more affected by DNA damage than... 

Bhat, K.R., Benton, B.J., Ray, R. (2006). Poly (ADP-rihose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, hut has no role in DNA ligase activation. J. Appl. Toxicol. 26 452-7. 

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