Environmental Protection Agency exposure assessment case studies

EPA released the first case study of cumulative risks from 24 OPs in food for scientific review in mid-2000. Public comments were solicited and several scientific panel (SAP) meetings were held on various aspects of EPA s quantitative methods. In December 2001 a preliminary OP-CRA (cumulative risk assessment) was released, this time encompassing 30 OPs, additional foods, more residue data and all major routes of exposure. Public comments were solicited again and another series of SAP meetings were held. The revised final OP-CRA was issued in June 2002 after more than 20 SAP meetings and four rounds of public comment (US Environmental Protection Agency, 2002). It is the most sophisticated and data-rich pesticide risk assessment ever carried out. 

Appendix B provides brief case studies of two pesticides, glyphosate and permethrin, for which a pre-existing risk assessment can help to put biomonitoring results into perspective. In both cases, the Environmental Protection Agency (EPA) has evaluated risks for a wide array of exposure scenarios as part of the reregistration process, and there are biomonitoring data whose interpretation could benefit from these risk assessments. 

A fairly detailed case study illustrating a probabilistic approach to both aggregate and cumulative assessments is described in the first part of this chapter. This case study focuses on chronic exposure (that is, a person s long-term average dose). The case study was prepared as part of a submission to the US Environmental Protection Agency (USEPA) in 1996. 

U.S. Environmental Protection Agency, 2007b. Lead Human Exposure and Health Risk Assessments for Selected Case Studies, vol.l. Human Exposure and Health Risk Assessments—Full Scale. Report No. EPA-452/R-07-014a. Office of Air (Juality Planning... 

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