Emollients cholesterol

As an emollient, squalene is expected to increase skin hydration due to skin surface occlusions. In addition, squalene is a substance believed to maintain moisture in the stratum corneum. Novel substitutes were researched for vernix caseosa which is a reported highly efficient barrier cream for facilitating stratum corneum hydration for barrier-deficient skins. For this purpose, various lipid fractions were mixed with squalene, triglycerides, cholesterol, ceramides, and fatty acids to produce a mixture that can generate similar compositions of vernix caseosa (Rissmann et ah,... 

However, TAGs and fatty acid are found abundantly in the human skin along with other components such as cholesterol and ceramides, more specifically in the human stratum corneum (outer layer of the skin) (58), which has been used to explain the high emolliency of some oils. Following this same rational, blends of other oils rich in oleic, linoleic, and palmitic acids such as olive, com, and palm oils are also widely used in cosmetics. 

Cholesterol is used in cosmetics and topical pharmaceutical formulations at concentrations of 0.3-5.0% w/w as an emulsifying agent. It imparts water-ahsorhing power to an ointment and has emollient activity. 

Cholesterol NF. [Croda Inc. Croda ChenuLtd.] Chcdesterol NF moisturizer, emollient, emulsifier. 

Dastar. [Croda Chem. Ltd.] Cholesterol condituHier, emollient, emulsifier for ddn and hair care prods. 

Forlan. [RITA] Lanolin, petrolatum, or cholesterol blends emulsion stabilizer, emollient, moisturizer, solubilizer, dispersant, plasticizer for personal care prods. solid absorption base. 

Solwax. [Van Schuppen] Alkoxylated lanolin or cholesterol derivs. emulsifier, foam stabilizer, softener, conditioner, emollient... 

Emollients are chemicals that coat the skin, preventing moisture from passing through. Oils are very effective emollients, but most people are put off by their sUppery feel. The challenge for cosmetics manufacturers is to find substances that prevent moisture loss but do not make the wearer feel like a greaseball. Cholesterol meets this challenge. It is readily absorbed into the surface of the skin, and it doesn t feel oily. 

Synonyms Cholest-5-en-3-ol, isooctadecanoate Cholest-5-en-3-ol, isostearate Derinition Ester of cholesterol and isostearic acid Empirical C45H80O2 Uses Emollient in cosmetics Trade Name Synonyms IS-CE [Kao Corp. SA http //www.kao.es]... 

Definition Ester of cholesterol and the fatty acids obtained from macadamia nut oil Uses Emollient in cosmetics Cholesteryl nonanoate CAS 1182-66-7 EINECS/ELINCS 214-658-3 Synonyms Cholest-5-ene-3p-yl nonanoate 5-Cholesten-3p-ol 3-nonanoate Cholesteryl pelargonate 3p-Hydroxy-5-cholestene 3-nonanoate o-Nonanoylcholesterol Definition Ester of cholesterol and nonanoic acid Empirical C36H62O2... 

Properties Oil, faint odor insol. in water si. sol. in alcohol sol. in lipids, org. soivs. m.w. 410.73 dens. 0.858-0.860 (20 C) m.p. -75 C b.p. 285 C (25 mm) ref. index 1.4965 (20 C) vise. 12 cps (25 C) flash pt. 200 C ref. index 1.496 (20 C) Toxicoiogy LD50 (oral, mouse) 5 g/kg, (IV, mouse) 1800 mg/kg mod. toxic by IV route si. toxic by ing. TSCA listed Precaution Combustible Hazardous Decomp. Prods. Heated to decomp., emits acrid smoke and irritating vapors HMiS Health 0, Flammability 1, Reactivity 0 Storage Photosensitive Uses Biochemical and pharmaceutical research a precursor of cholesterol in biosynthesis chemical intermediate for mfg. of pharmaceuticals, organic colorants, rubber chemicals, aromatics, surfactants bactericide antistat, emollient, lubricant, protectant,... 

The exact mechanism of action of moisturizers and emollients is still unknown. Theoretically, the improvement in the barrier function could be due to absorption of the moisturizer into the delipidized stratum corneum, acting as an effective barrier, as suggested in a study on the effect of petrolatum (Ghadially et al. 1992). Due to a better knowledge of the structural organization of the horny layer with corneocytes embedded in between lipid bilayers (ceramides, cholesterol and free fatty acids in approximately equal quantities), new emollients could be developed to supply the missing elements in the bilayer structure after acute or chronic irritant contact. However, applications of ceramides, linoleic acid and a variety of other fatty acids alone have been reported to actually delay barrier recovery in acetone-treated murine skin, despite the fact that these lipids are required for barrier homeostasis. The only treatments that allowed normal barrier recovery were applications of complete mixtures of ceramide, fatty acid and cholesterol, or pure cholesterol (Man et al. 

Body washes are another more recent introduction into the marketplace. These products have become a mainstay in the global market. Body washes can be simple formulas similar to those used for liquid handsoaps or complex 2-in-l oil-in-water emulsion, moisturizing formulations. These products contain a wide range of synthetic surfactants not typically found in bar soaps or liquid handsoaps, such as sodium monoalkyl phosphate and alkyl aminocarboxylates. It is not uncommon to find over 20 different components in these formulations, with no less than six or seven different surfactants. These products can also contain skin benefit agents, such as cholesterol, fatty alcohols, fatty acids, cationic polymers, and emollient oils to provide even milder-to-skin cleansing and in-use moisturization. 

Uses Moisturizer, emollient, superfatting agent, plasticizer, and excipient in pharmaceutical topicals, skin creams and lotions, ointments, baby cleansing and protecting creams, sun protection systems o/w coemulsifier and w/o emulsifier Features Rich source of cholesterol and other sterols manufactured to to GMP standards Regulatory EP... 

Uses Biochemical and pharmaceuticals research a precursor of cholesterol in biosynthesis chemical intermediate for mfg. of pharmaceuticals, organic colorants, rubber chemicals, aromatics, surfactants bactericide antistat, emollient, lubricant, protectant, vehicle in cosmetics, dermatologicals lubricant, vehicle for lubricating and finishing oils... 

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