Embryotoxic effect

Renhof M. 1984. Parathion-methyl (Folidol M actice ingredient) Study for embryotoxic effects on rabbits after oral administration. Bayer AG Institute of Toxicology, Wuppertal, West Germany. Unpublished Report No. 12907. [Pg.227]

Gupta PK, Chandra SV, Saxena DK. 1978. Teratogenic and embryotoxic effects of endosulfan in rats. Acta Pharmacol Toxicol 42 150-152. [Pg.296]

Rommereim DN, Buschbom RL, Sikov MR. 1985. Comparison of embryotoxic effects of intravenously administered 239Pu and 241Am in rats. Health Phys 49 122-123. [Pg.257]

Gale, T.F. 1978. Embryotoxic effects of chromium trioxide in hamsters. Environ. Res. 16 101-109. [Pg.119]

Hoffman, D.J. 1979. Embryotoxic effects of crude oil containing nickel and vanadium in mallards. Bull. Environ. Contam. Toxicol. 23 203-206. [Pg.523]

Fent, K. 1992. Embryotoxic effects of tributyltin on the minnow Phoxinus phoxinus. Environ. Pollut. 76 187-194. [Pg.628]

Korhonen, A., K. Hemminki, and H. Vainio. 1983. Embryotoxic effects of acrolein, methacrylates, guanidines and resorcinol on three day chicken embryos. Acta Pharmacol. Toxicol. 52 95-99. [Pg.771]

Increased abortion rate no death of does. Weight loss, reductions in feed consumption and fetal and embryotoxic effects, including reduced fetal weight and increased incidence in skeletal variations (Infurna etal. 1988)... [Pg.794]

Hoffman, D.J. and M.L. Gay. 1981. Embryotoxic effects of benzo[a]pyrene, chrysene, and 7,12-dimethyl-benz(a)anthracene in petroleum hydrocarbon mixtures in mallard ducks. Jour. Toxicol. Environ. Health 7 775-787. [Pg.1400]

Reinterpreting embryotoxic effects of low level chronic irradiation... [Pg.1736]

Korhonen A, Hemminki K, Vainio H. 1983a. Embryotoxic effects of phthalic acid derivatives, phosphates and aromatic oils used in the manufacturing of rubber on three day chicken embryos. Drug Chem Toxicol 6 191-207. [Pg.122]

Female mice and rats exposed 6 hours/day at concentrations of 10, 68, or 152 ppm during gestation had reduced maternal weight gain at the higher doses embryotoxic effects and increased resorptions occurred in the mice exposed at 68 and 152 ppm. ... [Pg.106]

Embryotoxic effects have occurred in rabbits exposed to hydroxylamine hydrochloride by intracoelomic injection. Subcutaneous or intravenous injection of pregnant rabbits with 50-650mg of hydroxylamine hydrochloride on gestational day 12 caused death or euthanasia of all rabbits within 30 hours. All maternally injected rabbits exhibited severe cyanosis, presumably due to methemoglobinemia. At 8 hours all embryos were dead from cardiovascular effects, which are considered to be secondary to the severe maternal toxicity. [Pg.398]

DeSesso JM Demonstration of the embryotoxic effects of hydroxylamine in the New Zealand White rabbit. Anat Rec 196 45A-A6A, 1980... [Pg.398]

Nagano K et al Embryotoxic effects of ethylene glycol monomethyl ether in mice. Toxicology 20 11 S-IM, 1981... [Pg.447]

Treatment of mice during gestation caused embryotoxic effects and a low incidence of malformations. Administration of 3.2mg/ kg/day to rats for 27 weeks caused irreversible histopathologic changes in the testes. ... [Pg.658]

Exposure of pregnant mice, rabbits, or rats produced slight embryotoxic effects at maternally toxic doses. ... [Pg.670]

Merker HJ et al (1988) Embryotoxic effects of thalidomide-derivatives in the non-human primate Callithrix jacchus. Arch Toxicol 61 165-179... [Pg.183]

Embryotoxic effect. Resin, administered orally to pregnant rabbits at a dose of 1 mL/ kg, was active k... [Pg.62]

Embryotoxic effect. Hot water extract of the Folger s instant coffee, administered by gastric intubation to pregnant mice at a dose of 1.28 mg/animal, was inactive Hot water extract of the roasted seed, administered in drinking water of pregnant rats at variable doses daily for 30 weeks, was inactive . [Pg.171]

Diuretic activity. Ethanol (70%) extract of the dried fruit, administered intravenously to dogs at a dose of 150 mg/kg, increased diuresis 1.7-fold ". Ethanol (95%) extract of the seed, administered orally to rats at a dose of 100 mg/kg, was inactive" . Seed essential oil, administered intravenously to dogs at a concentration of 4 pL/kg, produced 2.4-fold increase in urine flow and an increase in K, NaL and Cl excretion. Ethanol (70%) extract of the seed essential oil, administered intravenously to dogs at a dose of 20 mg/kg, produced 1.6-fold increase in urine flow" . Embryotoxic effect. Ethanol (95%) extract of the dried seed, administered by gastric intubation to pregnant rats at a dose of 40 mg/animal on days 4-6, was inactive" . A dose of 0.10 g/kg, administered by gastric intubation to pregnant rats on days 1-10,... [Pg.206]

Embryotoxic effect. Water extract of the dried leaf, administered by gastric intubation to pregnant rats, was active. Preimplantation and implantation periods were most sensitive . [Pg.306]

Korhonen, A., Hemminki, K. Vainio, H. (1983a) Toxicity of rubber chemicals towards three-day chicken embryos. Scand. J. Work Environ. Health, 9, 115-119 Korhonen, A., Hemminki, K. Vainio, H. (1983b) Embryotoxic effects of phtalic acid derivatives, phosphates and aromatic oils used in the manufacturing of rubber on three day chicken embryos. Drug chem. Toxicol, 6, 191-207... [Pg.172]

Harris SJ, Cecil HC, Bitman J. 1978b. Embryotoxic effects of polybrominated biphenyls (PBB) in rats. Environ Health 23 295-300. [Pg.429]

Single intraperitoneal injections of acrylonitrile of 32 mg/kg bw, given on the fifth and seventh days of pregnancy, induced an embryotoxic effect in mice from an inbred strain of AB Jena-Halle, but not in DBA and C57 Cl mice (Scheufler, 1980). [Pg.80]

Kankaanpaa et al. (1979) studied the embryotoxic effects of acrylonitrile using chick eggs, but did not find any clear evidence of teratogenicity. [Pg.80]

Tetrachloroethane causes central nervous system depression and is highly hepatotoxic in mice and dogs it produced embryotoxic effects and a low incidence of malformations in mice. A single oral dose (437 mg/kg bw) of 1,1,2,2-tetrachloroethane decreased the activity of some hepatic cytochrome P450-dependent monooxygenases and, to a smaller extent, that of UDP-glucuronosyl transferase (lARC, 1979). [Pg.821]

Treatment of AB-Jena and DBA mice with 300-400 mg/kg bw 1,1,2,2-tetrachloroethane per day during organogenesis produced embryotoxic effects and a low incidence of malformations (exencephaly, cleft palate, anophthalmia, fused ribs and vertebrae). The effects were related to the dose and period of treatment (lARC, 1979). [Pg.821]

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