EGFR

EGFR Receptor tyrosine kinase Inhibition of cell proliferation and colony formation decrease of in vivo tumorigenicity... [Pg.187]

Cetuximab Anti-EGFR Colorectal cancer, Head and Neck cancers... [Pg.603]

Total drug clearance is the sum of nonrenal clearance and renal clearance (Clren). According to the MDRD-2 formula, the estimated GFR (eGFR) is a function of serum creatinine (SCr in mg/dl) and age (Age in years). It has the unit ml/min per 1.73 mA2. [Pg.957]

T /2 = T /2norm/(l - fren -I- fren eGFR/GFRnorm) With... [Pg.957]

A = (Clnorm - Clfail) /eGFRnorm B = -/+ (Fdfail - Fdnorm)/eGFRnorm G = -/+ (PB%fail - PB%norm)/eGFRnorm With bi-exponential kinetics, it should be sufficient to linearly correlate beta with eGFR. [Pg.957]

The effect of hemofiltration on drug elimination can be estimated from serum creatinine (SCr), age, and the MDRD-2 formula to predict the combined effect of filtration rate (eGFR = GFRresidual + HFR) on drug clearance and drug half-life during hemofiltration. [Pg.958]

T /2 = 7T /2nonn/(l - fren 4- fren eGFR/GFRnonn) Cl = Clfail +A eGFR... [Pg.958]

Erlotinib (Tarceva ) competes with ATP in the HER1/EGFR ATP-binding pocket. It is used in the clinic in locally advanced or metastatic non-small cell lung cancer after failure of at least one chemotherapy regime [1, 3, 5]. [Pg.1012]

Gefitinib (Iressa ) Astra-Zeneca TKI EGFR Metastatic non-small cell lung carcinoma... [Pg.1193]

Cetuximab (Erbitux ) Merck mAb EGFR Metastatic colorectal cancer... [Pg.1193]

Cetuximab specifically binds the extracellular domain of EGFR. It has been approved in colorectal and head and neck cancer. However, unlike for trastuzu-mab, no clear correlation has been demonstrated between EGFR expression in cancer cell and efficacy of cetuximab. [Pg.1193]

ADCC. Cetuximab is approved for treatment of metastatic colorectal cancer (CRC) and squamous cell carcinoma of the head and neck (SCCHN). Interestingly, an adverse event, acneiform rash seems to correlate with a better response to cetuximab, while there is no such correlation with expression levels of EGFR assessed by immunohistochemistry. Further side effects are rare infusion reactions and hypomagnesia. Two other anti-EGFR antibodies approved for clinical use are the fully human antibody panitumumab (Vectibix)... [Pg.1255]

Cetuximab (Erbitux) Chimeric antibody, IgGi EGFR Ligand competition ADCC CRC SSCHN... [Pg.1255]

Panitumumab (Vectibix) Fully human antibody, lgG2 EGFR Ligand competition CRC... [Pg.1255]

Gefitinib (Iressa) TKI EGFR Inhibition of kinase activity - ATP-competitive NSCLC... [Pg.1255]

El-Sayed, I.H., Huang, X. and El-Sayed, M.A. (2005) Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanopartides in cancer diagnostics Applications in oral cancer. Nano Letters, 5, 829-834. [Pg.347]

Enzyme-adduct formation has also been successfully achieved with the Erbl and 2 (receptor tyrosine kinases from EGFR subfamily) [19, 20], suggesting that the tethered library-screening approach would also be amenable to protein kinases. [Pg.11]

There are very few reported studies outlining the use of homology modelling in protein kinases. Panigrahi and Desiraju [117] performed a simple comparison of a model of the EGFR kinase domain to an experimental... [Pg.53]

EGFR or ERB-BI Codes for epidermal growth factor (EGFR) receptor Glioblastoma, breast cancer, squamous carcinoma... [Pg.1279]

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