The EGF and EGFR Families

Much of the phenotypic overlap observed in ErbB knockout mice appears to arise from the importance of heteromeric receptor combinations in mediating growth and development of specific tissues. In particular, HER2 and HERS are unable to signal by themselves and must pair with another ErbB receptor to generate a signal. Despite much effort, no high-affinity 

EGF TGFa ARG BTC HBEGF ERG NRG1 NRG2 NRG3 NRG4 

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