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Cancer EGFR associated with

VanMeter AJ, Rodriguez AS, Bowman ED et al (2008) Laser capture microdissection and protein microarray analysis of human non-smaU cell lung cancer differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type. Mol Cell Proteomics 7 1902-1924... [Pg.212]

Mechanism of Action Ahuman epidermal growth factor that inhibits tyrosine kinases (TK) associated with transmembrane cell surface receptors found on both normal and cancer cells. One such receptor is epidermal growth factor receptor (EGFR). Therapea-tic Effect TK activity appears to be vitally important to cell proliferation and survival. Pharmacokinetics About 60% is absorbed after PO administration bioavailability is increased by food to almost 100%. Protein binding 93%. Extensively metabolized in liver. Primarily eliminated in feces minimal excretion in urine. Half-life 36 hr. [Pg.449]

Press OA, Zhang W, Gordon MA, Yang D, Luije G, Iqbal S, El-Khoueiry A, et al. Gender-related survival differences associated with EGFR polymorphisms in metastatic colon cancer. Cancer Res 2008 68 3037-3042. [Pg.684]

See other pages where Cancer EGFR associated with is mentioned: [Pg.779]    [Pg.857]    [Pg.71]    [Pg.1011]    [Pg.1194]    [Pg.338]    [Pg.223]    [Pg.532]    [Pg.195]    [Pg.388]    [Pg.328]    [Pg.344]    [Pg.399]    [Pg.76]    [Pg.94]    [Pg.104]    [Pg.124]    [Pg.318]    [Pg.34]    [Pg.117]    [Pg.354]    [Pg.56]    [Pg.275]    [Pg.34]    [Pg.1011]    [Pg.1194]    [Pg.806]    [Pg.202]    [Pg.428]    [Pg.27]    [Pg.4]    [Pg.2291]    [Pg.2375]    [Pg.2396]    [Pg.17]    [Pg.139]    [Pg.147]    [Pg.289]    [Pg.976]    [Pg.904]    [Pg.73]    [Pg.8]    [Pg.91]    [Pg.346]    [Pg.478]    [Pg.530]    [Pg.550]    [Pg.255]   
See also in sourсe #XX -- [ Pg.6 ]

See also in sourсe #XX -- [ Pg.6 ]



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Cancer associated with

EGFR

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