Effect of oleic acid

Dobson CL, Davis SS, Chauhan S, Sparrow RA, Wilding IR. The effect of oleic acid on the human ileal brake and its implications for small intestinal transit of tablet formulations. Pharm Res 1999 16 92-96. 

Lee J, Kellaway IW (2000) Combined effect of oleic acid and polyethylene glycol 200 on buccal permeation of [D-ala2, D-leu5]enkephalin from a cubic phase of glyceryl monooleate. Int J Pharm 204 137-144... 

Intestinal absorption studies of Mn-MP were undertaken in an effort to assess the viability of the metalloporphyrin as an oral hepatobiliary agent [101, 102]. Mixed micelles of Mn-MP complexed with monoolein and taurocholate were administered to rats, resulting in liver image enhancement 68% above baseline levels six hours after administration [101]. In pigs, the mixed micelle preparation showed variable enhancement over 24 hours. Observation that Mn-MP interacts with oleic acid vesicles [103] led to investigations of the effect of oleic acid on the absorption rate of Mn-MP from the small bowel into the circulatory system [102,104]. The increase in absorption of the complex was mediated by a decrease in the relaxivity of the metalloporphyrin resulting from the interaction with the lipid vesicles. 

Figure 9.8 Effect of oleic acid (OA) on metronidazole release at 10 percent loading and 400- to 450-gm film thickness.

H. Tanojo, H. E. Junginger, and H. E. Bodde, Effects of oleic acid on human trans-epidermal water loss using ethanol or propylene glycol as vehicles, Prediction of Percutaneous Penetration, Vol. 3 (K. R. Brain, V. J. James, K. A. Walters, eds.), STS Publishing, Cardiff, UK, 1993, pp. 319-324. 

H. W. Sauer, K. L. Babcock and H. P. Rusch (1956). High molecular weight phosphorus compound in nucleic acid extracts of the slime mould Physarum polycephalum. J. Bacteriol., 99, 650-661. W. B. Schaefer and C. W. Lewis (1965). Effect of oleic acid on growth and cell structure of Mycobacteria. J. Bacteriol., 90,1438-1446. 

Takeuchi, Y. et al. Effects of oleic acid/propylene glycol on rat abdominal stratum comeum lipid extraction and appearance of propylene glycol in the dermis measured by Fourier transform infrared/attenuated total reflectance (FT-IR/ATR) spectroscopy. Chemical and Pharmaceutical Bulletin 4/(8) 1434-1437, 1993. 

Fig. 1 Effect of oleic acid on propranolol bioavailability. (From Ref ll)...

In vitro tests have shown that oleic acid causes rupture of red blood cells (hemolysis), and intravenous injection or ingestion of a large quantity of oleic acid can therefore be harmful. The effects of oleic acid on alveolar and buccal epithelial cells in vitro have also been studied the in vitro and in vivo effects of oleic acid on rat skin have been reported. Oleic acid is a moderate skin irritant it should not be used in eye preparations. 

Gao S, Singh J. Effect of oleic acid/ethanol and oleic acid/propylene glycol on the in vitro percutaneous absorption of 5-fluorouracil and tamoxifen and the macroscopic barrier property of porcine epidermis. Int J Pharm 1998 165 45—55. 

Wang R, Cruciani-Guglielmacci C, Migrenne S, Magnan C, Cotero VE, et al. 2006. The effects of oleic-acid (OA) on distinct populations of neurons in the hypothalamic arcuate nucleus (ARC) are dependent on extracellular glucose levels. J Neurophysiol 95(3) 1491-1498. 

Bell SA, Kuntze I, Caputo A, Chatelain R (2002) Strain-dependent in vitro and in vivo effects of oleic acid anilides on splenocytes and T cells in a murine model of the toxic oil syndrome. Food Chem Toxicol, 40 19-24. 

Table 7. Effects of oleic acid on tbe spleen weight and number of metastatic tumor colonies in the livers of mice with intrasplenically implanted LLC1...

Tabic 9 Effects of oleic acid on the numbers of leukocytes, red cells, and the hemoglobin concentration in LLC-bearing mice1... 

Table 11. Effects of oleic acid on DNA synthesis in LLC cells, Matrigel-induced capillary-like tube network Formation from HMVEC, and the adherence ofLLC cells to HMVEC (in vitro)1...

Table 13. Effects of oleic acid on Matrigel-induced angiogenesis (in vivo)1...

A reduction of atherosclerotic complications is the major objective of long-term therapy with antihypertensive agents [78], Several studies were carried out on the effects of oleic acid and its congeners, such as elaidic and stearic acids, and on the structural properties of membranes. 

On the other hand, at the highest castor oil concentration studied (4% mim), a significant drop in lipase activity was observed. Probably, the lipase production was repressed by the continuous release of fatty acid due to the castor oil hydrolysis in the fermentation broth. Li et al. [23] observed the inducing effect of oleic acid in lipase production and showed that when oleic acid concentration was higher than 0.4% mim, it repressed lipase production. 

Carrillo, C., Cavia Mdel, M. Alonso-Torre, S. R. (2012). Antitumor effect of oleic acid mechanisms of action a review. Nutricion Hospitalaria, 27(6), 1860-5. 

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