Drugs iodine

Drug Iodine Principal Indication(s) Adhesive capsulitis and other soft-tissue adhesions microbial infections Treatment Rationale Iodine is a broad-spectrum antibiotic, hence its use in infections, etc. the scle-rolytic actions of iodine are not fully understood Iontophoresis 5°/o-10°/o solution or ointment from negative pole Phonophoresis 10% ointment... 

Hyperthyroidism may be treated in several ways. One of these is interference with the synthesis of the thyroid hormones, possibly by removal of iodine. Thiourea and cyclic thioureas have this effect and of such cyclic compounds, thiouracil (1030 R = H), its 6-alkyl derivatives (1030 R = Me or Pr) and thiobarbital (1031) are effective thyroid drugs. Today only propylthiouracil (1030 R = Pr) is widely used, probably because it has fewer side effects than the others (71MI21302). The thiouracils are made by the Principal Synthesis from a /3-oxo ester (1032 R = H, Me, Pr, etc.) and thiourea (45JA2197) their fine structures are experimentally based (64AF1004). 

Imidazole, 1 -hydroxy-2,4,5-triphenyl-3-oxides reactions, S, 455 Imidazole, iodo-nitrodehalogenation, 5, 396-397 Imidazole, 1-iodo-reactions, S, 454 stability, S, 110 Imidazole, 2-iodo-synthesis, S, 401 Imidazole, N-iodo-, S, 393 reactions, 5, 454 Imidazole, 4-iodo-5-methyl-iodination, 5, 400 Imidazole, 2-isopropyl-4-nitro-N-nitration, 5, 351 Imidazole, 2-lithio-reactions, S, 106, 448 Imidazole, 2-mercapto-l-methyl-as antithyroid drug, 1, 171 mass spectra, 5, 358 Imidazole, 1-methoxymethyl-acylation, S, 402 Imidazole, 5-methoxy-l-methyl-reactions... 

Since alterations of thyroid fimction by amiodarone are related to the iodine substitution of the drug, the iodine-free derivative dronedarone has been developed with similar electrophysiological effects as amiodarone. It seems to act also as a T3-anatgonist, but does not provoke hyperthyreoidism [1]. 

Mucolytic and anti-oxidant drugs include ambroxol, N-acetylcysteine, carbocysteine and iodinated glycerol. These drugs have no proven effect on lung function. At... 

No significant interactions have been reported when tiie expectorants are used as directed. The exception is iodine products. Lithium and other antithyroid drug may potentiate the hypotliyroid effects of these drug if used concurrently with iodine products. When potassium-containing medications and potassium-sparing diuretics are administered with iodine products, the patient may experience hypokalemia, cardiac arrhythmias, or cardiac arrest. Thyroid function tests may also be altered by iodine... 

Antithyroid drugp or thyroid antagonists are used to treat hyperthyroidism. In addition to the antithyroid drugs, hyperthyroidism may be treated by the administration of strong iodine solutions, use of radioactive iodine (131I), or by surgical removal of some or almost all of the tiiyroid gland (subtotal thyroidectomy). 

There is an additive bone marrow depression when methimazole or propylthiouracil is administered with otiier bone marrow depressants, such as the antineo-plastic drugs, or witii radiation therapy. When methimazole is administered with digitalis, there is an increased effectiveness of the digitalis and increased risk of toxicity. There is an additive effect of propylthiouracil when the drug is administered with lithium, potassium iodide, or sodium iodide When iodine products are administered with litiiium products, synergistic hypotiiyroid activity is likely to occur. 

Before a patient starts therapy with an antithyroid drug, die nurse obtains a history of the symptoms of hyperthyroidism. It is important to include vital signs, weight, and a notation regarding the outward symptoms of die hyperthyroidism (see Table 51-1) in the physical assessment. If die patient is prescribed an iodine solution, it is essential that die nurse take a careful allergy history, particularly to iodine or seafood (which contains iodine). 

When iodine solutions are administered, the nurse observes Hie patient closely for symptoms of iodism and iodine allergy (see Adverse Reactions). If these occur, the nurse withholds tlie drug and immediately notifies the primary health care provider. This is especially important if swelling around or in the mouth or difficulty in breathing occurs. 

Mr. Conrad will receive a dose of radioactive iodine from the primary health care provider. Discuss how you would prepare Mr. Conrad before the drug is administered. In preparation for dismissal, analyze the most important points to stress to Mr. Conrad about radioactive iodine... 

Discuss the pharmacotherapy of Graves disease, including the advantages and disadvantages of antithyroid drugs versus radioactive iodine, adverse effects, and patient monitoring. 

Excess production of thyroid hormone can be reduced in four ways iodides, antithyroid drugs, radioactive iodine, and... 

Antithyroid drugs are used as primary therapy for Graves disease or as preparative therapy before surgery or radioactive iodine administration. The decision to use antithyroid drugs as... 

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