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Drugs, chemopreventive

Chemoprevention The use of drugs, vitamins, or other agents to reduce the risk of or delay the development or recurrence of cancer. [Pg.1562]

Steele VE, Hawk ET, Viner JL and Lubet RA. 2003. Mechanisms and applications of nonsteroidal antiinflammatory drugs in the chemoprevention of cancer. Mutat Res 523-524 137-144. [Pg.174]

Walle T, Walle UK, Sedmera D, and Klausner, M (2006) Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention Studies in bioengineered human tissue. Drug Metab. Dispos. 34 346-350. [Pg.179]

Anti-neoplastic activity of UDCA was demonstrated first in the context of ulcerative colitis-associated colorectal carcinogenesis. Subsequently, encouraging (but not definitive) results have been obtained in clinical trials of UDCA for prevention of sporadic colorectal adenoma recurrence, which should prompt further evaluation of UDCA for polyp prevention, particularly given its excellent safety profile compared with other candidate chemoprevention agents such as the nonsteroidal anti-inflammatory drugs. [Pg.93]

Fahmy H, Khalifa S, KonoshtmaT, Zjawiony JK, Potent cancer chemopreventive activity, Marine Drugs 2 1—7, 2002. [Pg.153]

Based on the same principle of modulation of drug absorption, other less known botanicals could produce similar or different effects compared to St. John s wort. Rosemary (Rosemarinus officinalis Labiatae) is a commonly used dietary botanical that has been found to have a chemopreventive effect (24). Furthermore, in drug-resistant MCF-7 human breast cancer cells expressing P-glycoprotein, methanol extracts of Rosemary at two concentrations (16.5 and 85 pg/mL) inhibited the efflux and increased intracellular accumulation of doxorubicin and vinblastine, two chemotherapeutic drugs that are known substrates of P-glycoprotein. Treatment of drug-resistant cells with the extracts also increased the cytotoxic effects of doxorubicin. On the other hand, in wild-type MCF-7 cells that do not express... [Pg.28]

Eaton, E.A. et al., Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention, Drug Metab. Dispos., 24, 232, 1996. [Pg.36]

Ghazali, R.A. and Waring, R.H., The effects of flavonoids on human phenolsulphotrans-ferases Potential in drug metabolism and chemoprevention, Life Sci., 65,1625,1999. [Pg.36]

Because induction of DMEs can enhance clearance of xenobiotic chemicals, specific agents are being tested for potential prevention of chemically induced toxicity, especially for chemoprevention of cancer. Oltipraz, originally developed as an anti-schistosomal drug, induces multiple Phase... [Pg.186]

Cuendet, M. and Pezzuto, J.M., The role of cyclooxygenase and lipoxygenase in cancer chemoprevention, Drug Metabol. Drug Interact., 17, 109, 2000. [Pg.337]

Nuclear factor kappa B (NF-kB) serves as a central regulator of the human immune and inflammatory response, and is a family of inducible transcription factors found virtually ubiquitously in all cells and functions in a variety of human diseases including those related to inflammation, cancer, asthma, atherosclerosis, AIDS, septic shock, and arthritis. Due to its role in a wide variety of diseases, NF-kB has become one of the major targets for drug development. Inhibition of NF-kB activity potentially contributes to cancer chemoprevention [27,28]. [Pg.80]

Trosko JE and Ruch RJ (2002) Gap junctions as targets for cancer chemoprevention and chemotherapy. Current Drug Targets 3 465—482. [Pg.1219]

Oltipraz s—s, N. f Jl 4 CH3 N 1,2-dithiol e-3-thione Antischistosomal drug and cancer chemopreventive agent... [Pg.237]

Klampfer, L. Signal transducers and activators of transcription (STATs) novel targets of chemopreventive and chemotherapeutic drugs. Curr. Cancer Drug Targets 2006, 6, 107-121. [Pg.105]


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