Drug metabolism metabolites, identification

Cross species metabolism Metabolite identification DDI drug metab. enzymes and transporters... [Pg.549]

See also Drug Metabolism Metabolite Isolation and Identification Isotope Studies. Pharmacokinetics Absorption, Distribution, and Elimination Pharmacodynamics. [Pg.882]

See also Air Analysis Sampling. Chromatography Overview Principles. Clinical Analysis Sample Handling. Drug Metabolism Metabolite Isolation and Identification. Extraction Solid-Phase Extraction. Food and Nutritional Analysis Sample Preparation. Forensic Sciences Volatile Substances. Headspace Analysis Purge and Trap. Perfumes. Sample Handling Sample Preservation Automated Sample Preparation. Sampling Theory. [Pg.1223]

See also Drug Metabolism Metabolite Isolation and Identification. Nuclear Magnetic Resonance Spectroscopy Instrumentation. Nuclear Magnetic Resonance Spectroscopy-Applicable Elements Hydrogen Isotopes. Nuclear Magnetic Resonance Spectroscopy Applications Pharmaceutical. Nuclear Magnetic Resonance Spectroscopy Techniques Multidimensional Proton Surface Coil In Vivo Spectroscopy Using Localization Techniques. Polymers Synthetic. [Pg.3311]

See also Bioassays Overview. Drug Metabolism Metabolite Isolation and Identification. Infrared Spectroscopy Ovenriew. Liquid Chromatography Liquid Chromatography-Nuclear Magnetic Resonance Spectrometry Pharmaceutical Applications. Mass Spectrometry ... [Pg.3377]

See also Archaeometry and Antique Analysis Dating of Artifacts. Bioassays Ovenriew. Drug Metabolism Metabolite Isolation and Identification Isotope Studies. Fertilizers. Food and Nutritional Analysis Meat and Meat Products. Immunoassays, Techniques Radioimmunoassays. Isotope Dilution Analysis. Pesticides. Pharmaceutical Analysis Drug Purity Determination. Process Analysis Overview. Radiochemical Methods Pharmaceutical Applications. Water Analysis Industrial Effluents. [Pg.4171]

Nobilis M, Mijusek J, SzotakovA B, Jirasko R, Hol-capek, M, Chamseddin C, Jira T, Kucera R, Kunes J, Pour M (2013) Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies identification of nabumetone metabolites. J Pharm Biomed Anal 80 164-172... [Pg.176]

With the advent of modern LC/MS instrumentation and sophisticated software, metabolic profiling has gradually become a significant tool to support drug discovery. Early identification of active or toxic metabolites and characterization of metabolic liability of a particular structural series will significantly reduce the cycle time of the lead opti-... [Pg.432]

Hopfgartner, G. Zell, M. Q trap MS a new tool for metabolite identification, in Using Mass Spectrometry for Drug Metabolism Studies, ed. Korf-macher, W. A., CRC Press, 2004. [Pg.61]

Ma, S., Chowdhury, S.K. and Alton, K.B. (2006) Application of Mass Spectrometry for Metabolite Identification. Current Drug Metabolism, 7, 503-523. [Pg.161]

Ma SG, Chowdhury SK, Alton KB. Application of mass spectrometry for metabolite identification. Current Drug Metabolism 7, 503-523, 2006. [Pg.229]

Drug metabolism studies including identification of bioactive metabolites and blocking of metabolic inactivation. [Pg.83]

Kantharaj, E., Tuytelaars, A., Proost, P. E., Ongel, Z., Van Assouw, H. P., and Gilissen, R. A. (2003). Simultaneous measurement of drug metabolic stability and identification of metabolites using ion-trap mass spectrometry. Rapid Commun. Mass Spectrom. 17 2661-2668. [Pg.72]

Rourick, R. A., Jenkins, K. M., Walsh, J. P., Xu, R., Cai, Z., and Kassel, D. B. (2002). Integration of custom LC/MS automated data processing strategies for the rapid assessment of metabolic stability and metabolite identification in drug discovery. In Proceedings of the 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL. [Pg.157]

Jindal, S. P., and Lutz, T. (1986). Ion cluster techniques in drug metabolism Use of a mixture of labeled and unlabeled cocaine to facilitate metabolite identification. J. Anal. Toxicol. 10 150-155. [Pg.187]

Shirley, M. A., Wheelan, P., Howell, S. R., and Murphy, R. C. (1997). Oxidative metabolism of a rexinoid and rapid phase II metabolite identification by mass spectrometry. Drug Metab. Dispos. 25 1144-1149. [Pg.189]

Nassar, A. E., and Lee, D. Y. (2007a). Novel approach to performing metabolite identification in drug metabolism. J. Chromatogr. Sci. 45 113-119. [Pg.272]