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Drug interactions with

These, such as the black box that was the receptor at the turn of the century, usually are simple input/output functions with no mechanistic description (i.e., the drug interacts with the receptor and a response ensues). Another type, termed the Parsimonious model, is also simple but has a greater number of estimatable parameters. These do not completely characterize the experimental situation completely but do offer insights into mechanism. Models can be more complex as well. For example, complex models with a large number of estimatable parameters can be used to simulate behavior under a variety of conditions (simulation models). Similarly, complex models for which the number of independently verifiable parameters is low (termed heuristic models) can still be used to describe complex behaviors not apparent by simple inspection of the system. [Pg.43]

Na+/Ca2+ Exchangers. Figure 4 Molecular properties of drugs interacting with NCX. Scheme summarizing the potency, the mode of selectivity, the molecular site of action and the isoform specificity of drugs interfering with NCX activity. [Pg.806]

Ekins S. Predicting undesirable drug interactions with promiscuous proteins in silico. Drug Discov Today 2004 Mar 15 9(6) 276-85. Review. [Pg.552]

Valko, K., Du, G. M Bevan, C. D Reynolds, D. P., Abraham, M. H., Rapid-gradient HPLC method for measuring drug interactions with immobilized artifidal membrane comparison with other lipophilidty measrues. J. Pharm. Sci. 2000, 89, 1085-1096. [Pg.48]

L. G. Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interaction with biological membranes. [Pg.435]

Dimpfel, W. Sptller, M. Traber, J. and Nichols, D.E. Tele-stereo-EEG in the rat after injection of drugs interacting with serotonergic transmission. Inti Pharmaco EEG Group Symposium, Abstracts. Kobe, Japan, October 1988. [Pg.26]

Screen the patient s pharmacy profile for potential drug-drug interactions with anticoagulation therapy... [Pg.158]

Inform the patient about the potential drug-drug interactions with warfarin, including over-the-counter medications and dietary supplements (Tables 7-8, 7-9, and 7-10). Instruct the patient to call the health care practitioner responsible for monitoring warfarin therapy before starting any new medications or dietary supplements. [Pg.158]

Antacids also have clinically significant drug interactions with tetracycline, ferrous sulfate, isoniazid, quinidine, sul-fonylureas, and quinolone antibiotics. Antacid-drug interactions are influenced by antacid composition, dose, dosage schedule, and formulation. [Pg.263]

While generally not of major concern, omeprazole may inhibit the metabolism of warfarin, diazepam, and phenytoin lansoprazole may decrease theophylline concentrations. Drug interactions with omeprazole are of particular concern in patients who are considered slow metabolizers, as are approximately 3% of the Caucasian population. Unfortunately, it is unclear which patients have the polymorphic gene variation that makes them slow metabolizers.17 The metabolism of esomeprazole may also be altered in patients with this polymorphic gene variation. Patients on potentially interacting drugs should be monitored for development of drug-related problems. [Pg.264]

Analyze potential drug interactions with antiepileptic drugs. [Pg.443]

TABLE 27-4. Common Drug Interactions with Antiepileptic Drug36-38... [Pg.458]

Determine whether there are any drug interactions with the patient s current or home medication regimens. Do you need to adjust the dose of any medications for toxic or subtherapeutic concentrations from the drug interaction ... [Pg.470]

TABLE 33-3. Drug Interactions with Abused Drugs or Drugs Used to Treat Drug Abuse... [Pg.533]

There are currently no reported drug interactions with buprenorphine however, buprenorphine is metabolized primarily by CYP3A4... [Pg.533]

TABLE 34-9. Metabolism and Drug Interactions with Antipsychotics... [Pg.563]

TABLE 37-5. Pharmacokinetic Drug Interactions with Benzodiazepines44... [Pg.613]

Cite important drug interactions with oral contraceptives. [Pg.737]

TABLE 45-4. Commonly Seen Drug Interactions with COCs1 31... [Pg.746]

The use of duloxetine in stress urinary incontinence is complicated by (1) the potential for multiple clinically relevant drug-drug interactions with cytochrome P-450 2D6 and 1A2 inhibitors, (2) withdrawal reactions if abruptly discontinued, (3) high rates of nausea and other side effects, (4) the hepa-totoxicity that contraindicates its use in patients with any degree of hepatic impairment, and (5) its mild hypertensive effect. [Pg.804]

TABLE 52-6. Potential Drug-Drug Interactions with the Calcineurin Inhibitors and Sirolimus Mediated Through the CYP3A4 Isozyme11... [Pg.844]

There are several important drug-drug interactions with allopurinol. The effects of both theophylline and warfarin may be potentiated by allopurinol. Azathioprine and 6-mercaptopurine are purines whose metabolism is inhibited... [Pg.896]

Check the patient profile and talk with the patient to ensure that there are no significant drug interactions with other concurrent medications and therapies. [Pg.958]

Adverse effects with the tetracyclines include gastrointestinal upset drug interactions with dairy products, antacids, and iron and phototoxicity. Minocycline can also cause vestibular complications (headache and dizziness) and skin discoloration that is not typical with tetracycline and doxycycline.16... [Pg.964]

Is the patient taking the appropriate dose of each medication Are the doses adjusted for renal or hepatic failure Are the doses adjusted for drug interactions with concomitant medications ... [Pg.1274]


See other pages where Drug interactions with is mentioned: [Pg.1088]    [Pg.8]    [Pg.10]    [Pg.10]    [Pg.58]    [Pg.447]    [Pg.45]    [Pg.87]    [Pg.150]    [Pg.50]    [Pg.71]    [Pg.158]    [Pg.158]    [Pg.159]    [Pg.159]    [Pg.159]    [Pg.481]    [Pg.519]    [Pg.544]    [Pg.564]    [Pg.746]    [Pg.812]    [Pg.830]    [Pg.1260]   


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Alprazolam drug interactions with

Alprazolam interaction with other drugs

Aminoglycoside antibiotics interaction with other drugs

Amphetamines interaction with other drugs

Amphotericin interaction with other drugs

Anaesthesia interactions with other drugs

Angiotensin-converting enzyme inhibitors drug interactions with

Anticonvulsants interaction with other drugs

Antidepressant drugs interaction with foods

Antidepressants interaction with other drugs

Antiseizure drugs drug interactions with

Aspirin drug interactions with

Benzodiazepines interaction with other drugs

Beta blockers interaction with other drugs

Bupropion interaction with other drugs

Buspirone interaction with other drugs

Caffeine interaction with other drugs

Calcineurin inhibitors, drugs interacting with

Calcium channel blockers drug interactions with

Carbamazepine interaction with other drugs

Cardiac glycosides drug interactions with

Cephalosporins interaction with other drugs

Chloramphenicol interaction with other drugs

Cimetidine interaction with other drugs

Ciprofloxacin interaction with other drugs

Cisapride, drug interactions with

Citalopram interaction with other drugs

Clonidine interaction with other drugs

Clozapine interaction with other drugs

Contraceptives interaction with other drugs

Cyclosporine interaction with other drugs

Diazepam interactions with other drugs

Digoxin drug interactions with

Diltiazem interaction with other drugs

Disulfiram interaction with other drugs

Doxycycline drug interactions with

Drug Interactions with Targets or Receptors

Drug failure interactions with other drugs

Drug interactions benzodiazepines with antidepressants

Drug interactions carbamazepines with oral contraceptive

Drug interactions metronidazole with alcohol

Drug interactions with diet

Drug interactions with grapefruit juice

Drug interactions with herbal medicines

Drug interactions with plastics

Drug interactions, with lithium

Drugs Interacting with GFJ

Drugs interactions with elements and vitamins

Enzymes drugs interacting with

Erythromycin drug interactions with other drugs

Erythromycin interaction with other drugs

Estrogen interaction with other drugs

FDA Perspectives on the Use of Postmarketing Reporting Systems to Evaluate Drug Interactions with CAHP

Fluoxetine drug interactions with

Fluoxetine interaction with other drugs

Fluvoxamine drug interactions with

Fluvoxamine interaction with other drugs

Foods drug interactions with

Gabapentin interaction with other drugs

Guanethidine interaction with other drugs

Haloperidol interaction with other drugs

Herbal products drug interactions with

Herbs interactions with drugs

Hypoglycemic agents, oral, interaction with other drugs

Hypoglycemic drugs , drug interactions with

Imipramine interaction with other drugs

Insulin interaction with other drugs

Interaction of drugs with cyclodextrins

Interaction with Incorporated Drugs

Interaction with other drugs

Isoniazid interaction with other drugs

Itraconazole interaction with other drugs

Ketoconazole interaction with other drugs

Lamotrigine interaction with other drugs

Levodopa interaction with other drugs

Lithium interaction with other drugs

MAOIs drug interactions with

MAOls drug interactions with

Macrolide antibiotic interaction with other drugs

Methadone interaction with other drugs

Methylphenidate interaction with other drugs

Metronidazole interaction with other drugs

Mirtazapine interaction with other drugs

Monoamine oxidase inhibitors drug interactions with

Monoamine oxidase inhibitors interaction with other drugs

Natural products drug interactions with

Nefazodone drug interactions with

Nefazodone interaction with other drugs

Nitrates interaction with other drugs

Nonsteroidal anti-inflammatory drugs drug interactions with

Nucleic acids interactions with drugs

Omeprazole interaction with other drugs

Oxcarbazepine interaction with other drugs

Paroxetine interaction with other drugs

Penicillin interaction with other drugs

Phenolic Compounds in Grapefruit and Citrus with Potential Drug Interactions

Phenothiazines interaction with other drugs

Phenytoin interaction with other drugs

Probenecid drugs clinical interaction with

Propranolol interaction with other drugs

Quinidine interaction with other drugs

Receptors interaction with drugs

Rifampin interaction with other drugs

Risperidone interaction with other drugs

Salicylates drug interactions with

Sedative medications interaction with other drugs

Serotonin reuptake inhibitors, selective interaction with other drugs

Sertraline interaction with other drugs

Sibutramine interaction with other drugs

Stimuli-sensitive polymers for drug delivery and diagnostic systems interacting with biosurfaces

Sulfonamides interaction with other drugs

Tables Herbs Interacting with Drugs

Tetracycline interaction with other drugs

Theophylline interaction with other drugs

Thiazides drug interactions with

Thioridazine interaction with other drugs

Thyroid hormones interaction with other drugs

Tranylcypromine drug interactions with

Tricyclic antidepressants interaction with other drugs

Valproic acid interaction with other drugs

Venlafaxine interaction with other drugs

Verapamil interaction with other drugs

Vitamin drug interactions with

Warfarin drug interactions with

Warfarin interaction with other drugs

What Properties Are Shared by Drugs that Interact with P-Glycoprotein

Zidovudine drugs clinical interactions with

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