Drug interactions clinical significance

Hansten PD, ed. Drug Interactions Clinical Significance of Drug-Drug Interactions, 5th Ed. Philadelphia Lea and Febiger, 1985. 

Multiple drug interactions may occur with the glucocorticoids. Table 50-2 identifies select clinically significant interactions. 

TABLE 7-8. Clinically Significant Warfarin Drug Interactions... 

Antacids also have clinically significant drug interactions with tetracycline, ferrous sulfate, isoniazid, quinidine, sul-fonylureas, and quinolone antibiotics. Antacid-drug interactions are influenced by antacid composition, dose, dosage schedule, and formulation. 

CrCl greater than or equal to 30 to less than 50 mL/minute) and severe (CrCl less than 30 mL/minute) renal impairment respectively. Renal function monitoring is recommended prior to initiation and periodically thereafter. Adverse events in clinical trials included nasopharyngitis (5.2%), upper respiratory tract infection (6.3%), and headache (5.1%). Currently, no significant drug interactions are known. 

Schein, J. R. (1995). Cigarette smoking and clinically significant drug interactions. Ann. Phar-macother., 29(11), 1139-48. 

Numerous potential drug interactions are possible clinically significant drug interactions with oral contraceptives, warfarin, and oral dexametha-sone have been described. 

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